HIV Experts Debate Impact of Failed Vaccine

March 21, 2008— -- In the spring of 2007, it was the next great hope for the fight against AIDS. But by the fall, studies of an experimental vaccine against HIV suggested not only that it did not work, but that it actually put those who received it at greater risk of infection.

Now, AIDS experts are assessing the potential damage of the results of these trials to HIV vaccine research. And while some say the blow is enough to send scientists back to the drawing board, others counter that the findings of the studies are still useful, and research must continue.

At the forefront of the debate is Dr. Robert Gallo, co-discoverer of the human immunodeficiency virus (HIV) and head of the Institute for Human Virology in Baltimore. This week, Gallo told the Washington Post of the failed trial, "This is on the same level of catastrophe as the Challenger disaster," referring to the 1986 explosion of the space shuttle Challenger, which dealt a major blow to NASA's space exploration program.

It is a grim assessment with which some researchers agree.

"At this moment, AIDS vaccine trials are basically dead in the water," said Dr. Gary Simon, director of the Division of Infectious Diseases at George Washington University in Washington, D.C. "Furthermore, who would volunteer given the results?

"The hopes of an AIDS vaccine are dashed."

Dr. Charles van der Horst, professor of medicine at the University of North Carolina at Chapel Hill, concurs. "We need to go back to square one and stop the clinical trials until we have better lab and animal data as how to proceed on the vaccine front," he said.

But others say that though the outcome of the trial was unfortunate, it must not be viewed as a death blow to future HIV vaccine research.

"There is no reason to believe that an HIV vaccine cannot work," said Julia Hurwitz, an HIV researcher at St. Jude Children's Research Hospital in Memphis, Tenn. "There are good vaccine candidates that deserve testing in the HIV field … The field is over-reacting to an hypothesis that has not been proven."