Travelers arriving from Guinea, Liberia and Sierra Leone, where Ebola has killed more than 4,000 people since the worst outbreak of the virus in history began in March, will be given a home kit with a thermometer and Ebola information so that they can self-monitor and report to the CDC, according to the agency.
If they do not report, officials will track them down, the CDC said.
They will need to take their temperature twice daily and answer several questions about their symptoms, according to the CDC.
The program will focus on the six states that see about 70 percent of the traffic from these regions: Georgia, Maryland, New Jersey, New York, Pennsylvania and Virginia.
Some states may monitor these travelers in person.
Get real-time updates as this story unfolds. To start, just "star" this story in ABC News' phone app. Download ABC News for iPhonehere or ABC News for Android here. To be notified about our live weekend digital reports, tap here.