J&J vaccine booster shot raises antibody levels 9-fold, company says

The findings could inform the government's recommendations about booster shots

In the midst of a delta variant surge, a new study finds that giving a booster dose of the Johnson & Johnson shot six months after primary vaccination results in a nine-fold increase of a crucial antibody response, according to a company press release.

Meanwhile, a prior study found that people vaccinated with the Johnson & Johnson vaccine still had a durable immune response at least eight months later, even without a booster.

Collectively, the findings could help inform the U.S. government's recommendations about booster shots for the 14 million people who received the single-shot Johnson & Johnson vaccine.

Boosting after six months "appears to be safe, and boosts immune responses substantially," Dr. Dan Barouch, Ph.D., director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center, told ABC News.

The new data shows "a booster dose of the Johnson & Johnson COVID-19 vaccine further increases antibody responses among study participants who had previously received our vaccine,” said Dr. Mathai Mammen, Global Head, Janssen Research & Development, Johnson & Johnson, in prepared remarks.

Still, this new phase of the pandemic means federal health officials are now likely to endorse booster doses.

"We are prepared to offer booster shots for all Americans beginning the week of Sept. 20 and starting eight months after an individual’s second dose," said Centers for Disease Control and Prevention Director Rochelle Walensky, speaking at a press conference Wednesday.

But the Biden administration's Wednesday announcement on booster doses only included people who received the Pfizer or Moderna shots, omitting a specific recommendation for those who received Johnson & Johnson. Walensky said data on Johnson & Johnson could be expected "in the next few weeks" and that "with those data in hand, we will keep the public informed with a timely plan for J&J booster shots as well."

Pfizer and Moderna vaccines were authorized in December 2020, while Johnson & Johnson was authorized in February 2021. Because large clinical trials for the Johnson & Johnson vaccine began months later than the other two vaccines, data for this vaccine often takes a few weeks longer to be published.

The new data, which still has only been described in a press release and has not yet been peer-reviewed, will likely help inform recommendations about if, and when, booster doses will be needed for those who got the Johnson & Johnson shot.

"It’s some of the data people been asking for and waiting for and wanted to see," Barouch said.

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