Most states are seeing cases decreasing or at a plateau.
As the COVID-19 pandemic has swept the globe, more than 5.6 million people have died from the disease worldwide, including over 883,000 Americans, according to real-time data compiled by Johns Hopkins University's Center for Systems Science and Engineering.
About 63.7% of the population in the United States is fully vaccinated against COVID-19, according to data from the Centers for Disease Control and Prevention.
The omicron variant is estimated to account for 99.9% of all new cases in the U.S. as of Jan. 22, according to the CDC.
In early December, omicron was estimated to make up just 0.6% of new cases.
Delta now accounts for 0.1% of new cases nationally, forecasters estimate.
These estimates are the results of CDC modeling using recently available data.
-ABC News' Arielle Mitropoulos
Over 21 million new weekly cases were reported across the globe -- the most recorded since the beginning of the pandemic, according to the World Health Organization.
The U.S. (4,215, 852 new cases -- a 24% decrease from the previous week) reported the most, followed by France (2,443,821 new cases -- a 21% increase).
The U.S. also recorded 10,795 deaths -- the most of any nation.
-ABC News' Christine Theodorou
Nearly 20,000 Americans with COVID-19 are being admitted to hospitals each day -- an 8% drop over the last week, according to federal data.
But 13 states saw COVID-19-related hospital admission rates jump by at least 10%: Alaska, Alabama, Arkansas, Idaho, Kentucky, Nebraska, New Mexico, Oklahoma, Oregon, South Dakota, Utah, West Virginia and Wyoming.
Emergency department visits for diagnosed COVID-19 cases declined nearly 24% over the last two weeks, according to federal data.
While the U.S. case rate is steadily falling -- down by 15% in the last week to an average of 664,000 new cases -- case rates still remain higher than any other point of the pandemic, according to federal data.
Wisconsin is leading the nation in new cases per capita, followed by Rhode Island, Utah and South Carolina.
-ABC News' Arielle Mitropoulos
Elton John has tested positive for COVID-19, forcing him to postpone his concerts on Jan. 25 and Jan. 26 at the American Airlines Center in Dallas, according to a statement from the venue.
"Elton is fully vaccinated and boosted, and is experiencing only mild symptoms," the statement said. "Fans should hold on to their tickets as they will be honored at the rescheduled dates to be announced soon."
