COVID-19 updates: US cases at lowest point since Christmas

The first vaccine shipments for children under 5 could arrive at pediatricians' doors as soon as Feb. 21, according to a planning guide sent to states from federal health officials and obtained by ABC News.

Doses can ship once the FDA signs off. 

The FDA's independent advisory committee will meet on Tuesday and after that the FDA can issue an emergency use authorization. 

The CDC's independent advisory panel is expected to meet within days of the FDA's authorization. Once the CDC signs off on its panel's recommendations, vaccinations for kids under 5 can start. 

-ABC News' Sasha Pezenik

CDC Director Rochelle Walensky acknowledged that it's tough to make national guidelines to ease restrictions that will fit every different city and town.

"One of the challenging pieces has been how we make guidance that is general enough so that it can be applied to New York City and rural Montana and Indian country, which is our responsibility, and yet have it be specific enough so that people can get their questions answered," Walensky said in a webinar in hosted by the COVID-19 Vaccine Education and Equity Project.

Looking to the future, Dr. Peter Marks, the FDA's vaccine chief, said "Obviously the hope is -- and I think it's probably the 90% scenario -- is that we're going to now move into a period where ... the virus becomes endemic. And we will be living alongside it probably in a period where we will start to get yearly boosters for it."

But Dr. Sara Oliver, an epidemic intelligence service officer for the CDC, noted that, although there's a drop in cases, the same hasn't happened yet in hospitals.

"It's difficult to envision a time point where we can say COVID is over if we're still in a time period where our hospitals and ICUs are feeling the strain," Oliver said.

-ABC News' Cheyenne Haslett

Nevada Gov. Steve Sisolak on Thursday announced an immediate end to the state’s indoor mask mandate -- including for schools -- citing a rapid decline in cases and a drop in hospitalizations.

"Teachers & schools will no longer be required to wear masks but school districts will need to work with their local health authorities to have plans in place to deal with outbreaks," the governor tweeted.

He added, "Employers and organizations, including school districts, may set their own policies, and I encourage them to work with their employees and communities to ensure that policies are in place."

Masks in Nevada will only be required on public transit per federal law, or in special facilities like hospitals or long-term care facilities.

-ABC News' Matthew Fuhrman

More than 80,000 Americans have died this year due to COVID-19. In just the last week, 16,100 Americans have died of the virus, according to federal data.

Even as hospitalizations continue to fall, COVID deaths continue to average around 2,300 per day, data provided by HHS and the CDC show. This is still below the peak average number of daily deaths which reached 3,400 deaths a day last winter.

Mississippi currently holds the highest seven-day death rate in the U.S., followed by Virginia and South Carolina, according to federal data.

On average, nearly 12,700 Americans are being admitted to hospitals each day for COVID, down 24.5% in the last week, federal data shows.