About 64.3 million Americans ages 12 and older are completely unvaccinated.
More than 731,000 Americans have died from COVID-19 while over 4.9 million people have died from the disease worldwide, according to real-time data compiled by the Center for Systems Science and Engineering at Johns Hopkins University.
Just 66.9% of Americans ages 12 and up are fully vaccinated against COVID-19, according to data from the Centers for Disease Control and Prevention.
In the United Kingdom, cases are up 16% since last week, officials said Wednesday. As winter nears, Health Secretary Sajid Javid warned that infections could go as high as 100,000 per day.
Deaths, however, remain low in the country. Officials are encouraging residents to get booster shots.
-ABC News' Joe Simonetti
Montana and Wyoming are now leading the nation in cases, followed by Idaho, Alaska, North Dakota and West Virginia, according to federal data.
Two states in the upper Midwest are seeing notable upticks in daily infections: Michigan and Minnesota have both seen case averages jump by more than 25% in the last month.
Hospital admissions in the U.S. have dropped by about 10.7% in the last week, according to federal data.
However, thousands of Americans are still dying every week. The daily death average -- 1,250 -- is higher than this time one year ago, before any vaccines were available.
-ABC News' Arielle Mitropoulos
Beginning Wednesday, states can start reserving vaccines for kids ages 5 to 11, though vaccines won't start shipping yet.
The government has purchased enough shots for all 28 million children ages 5 to 11 in the U.S.
On Oct. 26, the FDA advisory committee is expected to have a public discussion and have a non-binding vote on the matter. Within days of that vote, the FDA is expected to authorize the vaccine for kids ages 5 to 11.
On Nov. 2 and Nov. 3, a CDC committee is expected to have a public discussion and non-binding vote.
The CDC director is likely to issue a formal recommendation within hours of the expected Nov. 3 vote. Administration of vaccine for 5- to 11-year-olds may begin as soon as the CDC director signs off.
-ABC News' Eric M. Strauss
The FDA could authorize Moderna and Johnson & Johnson booster shots for some populations as soon as Wednesday.
Meanwhile, the CDC independent advisory committee is meeting Wednesday to discuss vaccines in general. The committee is expected to debate Moderna and Johnson & Johnson on Thursday, discussing who boosters should be recommended for and if mixing and matching vaccines should be permitted.
A non-binding vote is expected at the end of Thursday.
The CDC director is expected to make the final recommendations shortly after the vote, which could come as soon as Thursday night or Friday morning.
-ABC News' Eric M. Strauss
