Some of the highest death tolls are in Texas, Georgia and North Carolina.
The United States is facing a COVID-19 surge this summer as the more contagious delta variant spreads.
More than 672,000 Americans have died from COVID-19 while over 4.6 million people have died from the disease worldwide, according to real-time data compiled by the Center for Systems Science and Engineering at Johns Hopkins University.
Just 63.6% of Americans ages 12 and up are fully vaccinated against COVID-19, according to data from the Centers for Disease Control and Prevention.
In Texas, 126,687 children have tested positive for COVID-19 since the school year started, according to state data. But there is a sharp decline in new cases in the last week. More than 5 million students are in Texas schools.
At least 24,476 staff members at Texas schools have tested positive, according to state data.
-ABC News' Gina Sunseri
Indiana University Health, the state's largest network of physicians, said 125 employees have left after choosing to not get vaccinated.
All workers were required to be fully vaccinated by Sept. 1. Those who didn't were given a two-week unpaid suspension ending Sept. 14, and those who still didn't agree to the shot by that point "left the organization," according to a statement by IU Health.
-ABC News' Will McDuffie
An art exhibit commemorating the Americans who died from COVID-19 is opening to the public on Friday.
The exhibit, which will run until Oct. 3, displays more than 660,000 white flags on the National Mall at the base of the Washington Monument.
This is the largest participatory art installation on the National Mall since the AIDS Memorial Quilt.
Newport Independent Schools in Kentucky has canceled all classes on Friday due to an increase in the number of sick or quarantined students, the district said.
Classes will be virtual on Monday and Tuesday. The district said it plans to return to in-person learning on Wednesday.
