US Strikes ISIS Targets in Syria With Tomahawk Missiles and Stealth F-22 Raptor

Five Arab nations are involved in the airstrikes.

The United States and its allies carried out 14 airstrikes against ISIS targets in Syria, according to a Centcom statement released early this morning. The operation marks the first time the United States has launched strikes in Syria, a new front in the battle against the terror group.

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Separately, the United States also conducted eight strikes against Khorasan Group targets west of Aleppo to include training camps, an explosives and munitions production facility, a communication building and command and control facilities, Centcom said. The strikes were carried out only by U.S. assets.

U.S. officials have spoken publicly in recent days about how the Khorasan Group poses as much of a direct threat to the United States as ISIS.

A U.S. official had said the Arab nations would be dropping bombs, not just providing support.

The United States and its Arab partners used "a mix of fighter, bomber, remotely piloted aircraft and Tomahawk Land Attack Missiles" to conduct the 14 strikes against ISIS targets, Centcom said.

The stealth F-22 Raptor took part in the mission, a U.S. defense official said, marking the first time the pricey, controversial aircraft has been used in a combat operation.

"The United States employed 47 TLAMs launched from USS Arleigh Burke and USS Philippine Sea operating from international waters in the Red Sea and North Arabian Gulf, as well as U.S. Air Force, Navy and Marine Corps fighter, remotely piloted and bomber aircraft deployed to the U.S. Central Command area of operations," Centcom said.

ABC News consultant Col. Stephen Ganyard said, "This is almost like a Desert Storm where we went in with lots of firepower, everything that the United States has. All of the best gear is going into this fight because we have to treat it like a very high-threat environment."

The ministry issued a brief statement, carried by Syrian state media, saying that "the American side informed Syria's permanent envoy to the U.N. that strikes will be launched against the Daesh [ISIS] terrorist organization in Raqqa."

U.S. State Department spokeswoman Jen Psaki issued a statement this morning, saying, "The Syrian regime was notified of our intent to take direct action, but we did not seek the regime's permission nor coordinate our actions with the Syrian government, nor did Secretary Kerry send a letter to the Syrian regime."

Other officials had said before that surveillance aircraft have been flying over Syria for weeks gathering information on potential ISIS targets such as training camps, command and control areas, warehouses, and supply routes.

In a national address Sept. 10, President Obama said the first part of his strategy to counter ISIS was to "conduct a systematic campaign of airstrikes against these terrorists."

"Moreover, I have made it clear that we will hunt down terrorists who threaten our country, wherever they are. That means I will not hesitate to take action against ISIL [ISIS] in Syria as well as Iraq," Obama said. "This is a core principle of my presidency: If you threaten America, you will find no safe haven."

As of Monday, the U.S. had launched 194 strikes against ISIS in Iraq, according to Centcom.

U.S. Ambassador to the United Nations Samantha Power Sunday told ABC News' "This Week" that America would not conduct airstrikes in Syria alone. But already Secretary of State John Kerry claimed that some 40 countries, including a number of Arab nations, have offered various levels of support to the anti-ISIS effort. France announced last week it would join in airstrikes in the battle against ISIS.

ABC News' Jonathan Karl and Anthony Castellano contributed to this report.