With the hearing wrapped, after about two hours of arguments, the Supreme Court appeared highly skeptical of the challenge to the mifepristone regulations brought by a group of anti-abortion doctors -- suggesting recent steps to ease access to the medication used by millions of American women may be allowed to stand.

At the heart of the case are steps taken by the FDA in 2016 and 2021 to roll back safety measures around the pill, which was first approved for use in 2000.

The plaintiff doctors -- who do not prescribe mifepristone, use mifepristone or otherwise perform abortions -- claim that wider availability of the drug was authorized improperly and has adversely impacted them, forcing them to care for women in emergency rooms suffering complications from the pill, often in violation of their conscience.

While conservative-leaning Justices Samuel Alito and Clarence Thomas were the most sympathetic to the legal challenges, for the most part, the court on Tuesday steered clear of openly second-guessing FDA’s scientific analysis of mifepristone.

A majority of the justices, across the ideological spectrum, expressed doubt during the arguments that the doctors had sufficiently demonstrated legal standing that they had been directly harmed by the FDA’s mifepristone rule changes.

“It makes sense for individual doctors to seek a [conscience] exemption but they already have that,” said liberal-leaning Justice Ketanji Brown Jackson. “What they are asking for here is -- in order to prevent them from ever having to do these kinds of procedures -- that everyone else should be prevented from getting access to that medication. How is that not overbroad?”

That view was echoed by conservative-leaning Justice Neil Gorsuch.

Erin Hawley, the attorney for the doctors, was repeatedly pressed to provide specific examples or testimony from a physician who had been forced to violate his or her conscience in treating a mifepristone patient but she could not do so.

Solicitor General Elizabeth Prelogar, defending the FDA on behalf of the Biden administration, warned of "profound harm" for women and for drug companies working with the FDA should the lower court's restrictions on mifepristone remain.

-ABC News' Lalee Ibssa and Devin Dwyer

Solicitor General Elizabeth Prelogar gave a brief rebuttal on behalf of the federal government, summarizing their view that respondents do not have standing and that their sought remedy of nationwide relief is not warranted.

"They have said they fear there will be emergency room doctors somewhere, someday who might be presented with some woman suffering an incredibly rare complication and the doctor may have to provide treatment, notwithstanding the conscience protections," she said.

"We don't think that harm has materialized -- but what the [lower] court did to guard against that very remote risk was issue sweeping nationwide relief that restricts access to mifepristone for every single woman in this country and that causes profound harm," she added. "It harms the agency, which had the courts come in and displace the agency's scientific judgments. It harms the pharmaceutical agency that is sounding alarm bells that this would destabilize the system for approving and regulating drugs. And it harms women who need access to medical abortions under conditions the FDA determined were safe and effective."

Erin Hawley, the attorney for Alliance Defending Freedom representing the plaintiffs, said they are "harmed" without an injunction of mifepristone because it may require them to treat people experiencing abortion complications and "take an unborn life."

Justice Ketanji Brown Jackson asked Hawley asked how often would it be that the plaintiffs have to complete the procedure "in the way that you are describing?"

Hawley said plaintiffs have treated people experiencing abortion complications "dozens of times" and even said treatment may require "scraping out a uterus". However, she did not provide specific numbers.

Justice Elena Kagan, continuing the court's interest in the plaintiff's standing to bring this case, pressed attorney Erin Hawley on her "conscience harm" argument.

"You need a person. You need a person to be able to come in and meet the court's regular standing requirements," Kagan. "So, who's your person?"

Hawley pointed to one doctor, Dr. Christina Francis, whose partner had to perform a dilation and curettage (or a D&C) due to a life-threatening emergency for a woman who had taken abortion medication. Kagan asked if the doctor stated her objection at that time, which Hawley said they did not.

"The way people with conscience objections do this is they make those objections known," Kagan said. "That may be harder, that may be easier in a particular context but most hospitals have mechanisms in place, routines in place to ensure the doctors who are allowed to do this in advance and are allowed to it at the moment."

Justice Elena Kagan pressed Solicitor General Elizabeth Prelogar on the "arresting" statement from the government that this case marks the first time any court has restricted access to an FDA-approved drug.

"That is still to our knowledge the only time a court has done that," Prelogar responded.

"We have seen a disturbing trend of courts sometimes also overriding FDA's judgment to try to grant greater access to drugs and that overrides FDA expert judgment about what's necessary to ensure safe use," she continued. "And no matter which direction you come at it from we, on behalf of FDA, think that courts have no business making those judgments."