With Democrats working hard in the chamber to match the applause usually generated by 1,600, Biden strode to the podium, turning to Speaker Nancy Pelosi to ask if he could remove his mask, revealing a smile.
Biden turned to the pandemic, acknowledging the unusual surroundings, but setting the theme for the address: Opportunity.
"Tonight, I come to talk about crisis and opportunity. About rebuilding a nation, revitalizing our democracy and winning the future for America," he said. "After 100 Days of rescue and renewal, America is ready for takeoff. We are working again. Dreaming again. Discovering again. Leading the world again. We have shown each other and the world: There is no quit in America."
Biden touted the $1.9 trillion COVID-19 relief plan and the ongoing vaccinations across the country. He then urged Americans to immediately to take advantage of those shots.
"Go get vaccinated, America!" Biden shouted. "Go and get the vaccination. They're available. You're eligible now," he said to a loud round of applause.
-ABC News' Sarah Kolinovsky