"I hope you know how grateful I am to all of you," Biden said.
Democrats kicked off their convention Monday with a who's who of guests who all touted Vice President Kamala Harris' run for the White House.
Several topics came up during the night including the future of reproductive rights and Project 2025.
Harris made a surprise appearance after several Democratic VIPS took the stage, including Rep. Alexandria Ocasio-Cortez.
The main stars of the night were some of the Democrats' longstanding figures including Secretary of State Hillary Clinton.
But the main spotlight came as President Joe Biden spoke to the cheering crowd, reflecting on his four years as president and his decision to "pass the torch" to Harris.
A march organized in support of Palestinians in Gaza during the DNC has started, hours before its first night of programming kicks off.
Organizers with the Coalition to March on the DNC, which represents more than 200 activist organizations, said about 15,000 people were present for a rally held in Union Park, near the convention site, ahead of the march.
Biden continues to "fine tune" his speech after working on it over the weekend and is in "great spirits" as he heads to the convention, White House press secretary Karine Jean-Pierre told reporters aboard Air Force One.
"Yeah, look, the president is certainly going to continue to fine tune the speech, if you will. He had an opportunity to work on it this past weekend with Mike Donilon and Vinay Reddy, and so he's very much looking forward to this moment. As I just said, it is a fulfilling moment for him, and he's excited. He's excited," Jean-Pierre said.
"It's a big night. He's looking forward to it. He's looking forward to addressing the Democratic Party and and obviously the nation. It's a big night," she added
Jean-Pierre said Biden was in a good mood on the plane ride over.
"He's in great spirits and I think what you'll see is a president who has put his kind of his personal agenda aside and putting the country first, and that's who he's always been throughout his career, more than 50 years," Jean-Pierre said.
Read more about what observers expect from Biden's opening night speech here.
-ABC News' Cheyenne Haslett
The first mass rally during convention week in Chicago kicked off Monday afternoon in Union Park, located about four blocks east of the United Center, where the Democratic National Convention is being held.
Organizers with the Coalition to March on the DNC, which represents more than 200 activist organizations that gathered Monday in support of Palestinians in Gaza, said about 15,000 people were present.
ABC News spoke with several protesters ahead of the event. Many were native Chicagoans like Ken Justus, 68, who rode his bicycle, brandishing a "Swing Left" sign and sleigh bells. He said he still plans to vote for Vice President Kamala Harris.
"I want to make sure we still have a government," he said. His motto: "Vote blue no matter who."
Nearby, a coalition of nearly two dozen women from Indiana held banners to represent their organization, Jewish Voices for Peace. Their aim, said national board member Malkah Bird, 45, was to put pressure on the White House "no matter who is in office."
"We want our money reinvested in the U.S. to help our communities and not used to bomb Palestinians," Bird said.
One man, who asked ABC News not to use his name, said this was the first protest he had ever attended in his life. What motivated him, he said, was the "hypocrisy" of the administration's support of Ukraine while sending arms to Israel.
"If we want to be the leader of the free world, we need to exercise the responsibility of being the leader of the free world," he said.
Joshua Hansom, 52, traveled from Asheville, North Carolina, hoping to encourage people of all political stripes to come together through soccer. He passed cards to passersby encouraging them to join him to play soccer for two scheduled matches near Buckingham Fountain along the city's lakefront.
What will come out of it?
"Hopefully some solutions," he said. "At least some unity."
-ABC News' Mark Guarino
President Biden and first lady Jill Biden boarded Air Force One just after 2 p.m. ET to depart for Chicago.
They were followed by Peter Neal, the husband of Biden's granddaughter Naomi Biden.
Traveling with the president are key members of his staff, including chief of staff Jeff Zients and senior advisers Mike Donilon and Steve Ricchetti. White House press secretary Karine Jean-Pierre will gaggle with reporters during the flight.
