Harris laid out her experience on the global stage as vice president, saying she has "confronted threats to our security, negotiated with foreign leaders, strengthened our alliances and engaged with our brave troops overseas."

"As commander-in-chief, I will ensure America always has the strongest, most lethal fighting force in the world. And I will fulfill our sacred obligation to care for our troops and their families, and I will always honor and never disparage their service and their sacrifice," she said, as the crowd broke out into a chant of "U.S.A.!"

Harris turned to the issue of immigration talking about the need to come up with legislation to properly secure the border.

On Thursday, Trump was at the border and slammed her for what he called failed policies.

Harris reminded that Congress was close to bringing a bipartisan bill that was backed by border patrol agents and others. She vowed to revive that bill.

"I refuse to play politics with our security, and here is my pledge to you as president, I will bring back the bipartisan border security bill that he killed, and I will sign it into law," she said.

1:17

Harris at the DNC vows to sign border bill that Trump derailed

"I will bring back the bipartisan border security bill that he killed, and I will sign it into law," she said.

Harris struggled to find her role in the first few years of the Biden administration, but began to shine when talking about the fight for reproductive rights after the fall of Roe v. Wade.

"Let's be clear about how we got here, Donald Trump hand picked members of the United States Supreme Court to take away reproductive freedom, and now he brags about it," she said.

She then turned her ire to Republicans in Congress.

"Why exactly is it that they don't trust women?" she said. "Well, we trust women."

3:13

Harris at the DNC: Trump, others are 'out of their minds' on reproductive rights

"Donald Trump hand picked members of the United States Supreme Court to take away reproductive freedom, and now he brags about it," she said

Second gentleman Doug Emhoff, seated with his children and Harris' sister Maya, was seen wiping his eyes after Harris walked out to the lectern. He was the first person to receive a shout-out from the vice president, who remarked on their 10th wedding anniversary.

Her running mate, Tim Walz, was also looking on with emotion as she took the stage.