After knocking off a couple of Democratic incumbents, Republicans may not only defend but potentially increase their 51-seat majority as additional races are called throughout the night.
In Indiana, Republican Mike Braun knocked off Democratic Sen. Joe Donnelly, while in North Dakota GOP Rep. Kevin Cramer beat Sen. Heidi Heitkamp.
Democrats also failed to capitalize on potential gains in Texas, where Sen. Ted Cruz fended off Democratic challenger Beto O;Rourke, and in Tennessee, where Rep. Marsha Blackburn defeated Democrat Phil Bredesen.
The Senate GOP Conference's leadership ranks are not expected to change much. Senate Majority Leader Mitch McConnell is widely expected to remain atop the conference, with Sen. John Cornyn as his top deputy.
Heading into Election Day, Democrats were not expected to fare as well in the Senate as in the House of Representatives.
By failing to pick up the two seats needed, it's unclear whether the Democratic caucus' leadership ranks will change. Senate Minority Leader Chuck Schumer is widely expected to retain his post as the Democratic leader.