The two combatants will fight for the vacant WBO Welterweight title, and this will decide who is the better pugilist, as they have fought two times prior. Bradley won the first by a highly questionable split decision in 2012, then Pac Man won by unanimous decision in 2014.
In Manny's swan song, can he regain the luster he lost by losing the biggest fight of his career to Floyd Mayweather last May, or will Bradley cement his place in boxing history as a top Welterweight with a definitive win?
Let's take a look at where the money is going in Vegas, picks from boxing sharps and my best bet for the fight.
Where is the money going?
Jeff Sherman, assistant race and sportsbook manager at the Westgate Las Vegas SuperBook, opened Pacquiao -265 and Bradley +225.
"It's been steady action. Nothing big, but all on Bradley lowering the current price to Pacquiao -210 and Bradley +180", Sherman said.
Sherman hung the rounds prop at 10.5 over -360 and under +300. Sherman said they have had a little action on the over, but nothing big. As far as the overall handle, it hasn't been too big thus far. "For a supposedly bigger-name event in town, it's not pulling in what the other two [Pacquiao-Bradley bouts] did at this point."
When asked if they expect bigger handle come fight time, he said, "We will see more wagers on fight day, but I think the prevailing action will be on the Masters, as there is no real buzz on this fight, maybe because Pacquiao is on his way out. I really don't know."
At the Wynn, Johnny Avello, director of race and sports operations, opened the fight with Pacquiao -270 and Bradley +210. He got bet down to Pacquiao -210 and Bradley +180. He's going to hang the total Saturday at 12 full rounds over -200 and under +170.
"Action has been pretty one-sided on the underdog. I think the bettors are wondering what is on Pacquiao's mind other than boxing. Bradley wants this badly, and I can see why the action thus far reflects that," Avello said.
"This will be the lowest handle of any Pacquiao fight we have had," he said. "He has a tremendous following that we haven't seen and come support him as of yet."
Experts weigh in
Evan Young (boxing sharp): "They have fought 24 previous rounds and Pacquiao has won 18 of them. This fight hinges on what Pacquiao brings to this dance. Bradley will be well trained and ready to go. Bradley is world class and nearly elite, while Pacquiao was once elite but has obviously dipped. I'm going with Bradley to outhustle and outwork the Filipino dynamo for a close win in a distance fight, perhaps in the 115-113 range."
Stephen "Breadman' Edwards (trainer): "Bradley by decision. Pacquiao is almost shot and unmotivated. Two years is a long time ago that Pac beat Bradley."
Chris Capuano (boxing sharp): "Bradley is as tough as nails, more than battle tested. But as we've seen in their first two matches that he lacks the speed it takes to keep up with Pac. Teddy or no Teddy, Pac will outbox and outscore Timothy yet again to score an easier-than-expected unanimous decision. I got Pac by UD."
Quante Kent (boxing sharp): "Pac Man has not had a knockout win since 2009, and he is now 37 years old. Timothy Bradley, who won the first fight of their trilogy, is now on the upward swing with Teddy Atlas in his corner. The two worked great together in their first appearance, and I believe their magic will continue with a dominant UD win."
"Iceman" John Scully (trainer): "I like Timothy and I think he has more belief in himself now than at any time, due to his dealings with Teddy. But I still think Pac has enough left to duplicate the success he's had with him. Once in there, I think they're both going to revert back to what works for them. And what worked for Tim wasn't quite enough, in my opinion."
Marcus Figueroa (boxing sharp): "They've fought 24 rounds and I gave Pac 20 of them. It's hard to see it playing out differently the third time. PacMan UD, 116-112."
Eric Bradley (boxing trainer): "The keys to this fight are unique, usually noticed by those behind the scenes or true boxing aficionados. The difference in this fight is Atlas. Bradley is a good listener. My head says Pacquiao, but my heart says Teddy and Bradley win."
Peter Clarke (boxing sharp): "Bradley by decision. Inactivity and age finally catch up to Pacquiao. Bradley seems rejuvenated by Atlas. He never seemed to listen completely to what Joel Diaz was telling him, but Atlas seems to be able to motivate Bradley."
Comparing the fighters
Betting the fight
Pacquiao: The 37-year-old multidivisional champion had one of the most impressive runs in boxing from 2007 until 2011. He beat the likes of Marco Antonio Barrera, Juan Manuel Marquez, Oscar De La Hoya, Ricky Hatton, Miguel Cotto, Joshua Clottey, Antonio Margarito and Shane Mosley. It was in easy fashion, and his popularity was at an all-time high. Since losing a contested decision to his current foe, Bradley, in 2012, Pacquiao lost by a disturbing knockout to nemesis Juan Manuel in 2012 and has gone 3-3 in his past six fights. In his most recent fight, boxing's biggest matchup in decades, he was made to look ordinary to boxing's former pound-for-pound champion, Floyd Mayweather, and after the fight an injury to Pacquiao's left shoulder was mentioned as a reason for his performance.
Bradley: The 32-year-old has amassed a 33-1-1 record but has never been given maybe the proper respect he deserves by the boxing community, including myself. He holds wins over Junior Witter, Edner Cherry, Kendall Holt, Nate Campbell, Lamont Peterson, Devon Alexander, Juan Manuel, Ruslan Provodinkov and, disputed or not, Pacquiao. He recently teamed up with trainer Teddy Atlas and in his most recent fight did something no one had done before: demolished Brandon Rios. He comes to fight in shape every time, offers no excuses and is certainly underrated in every aspect. Watch the Provodinkov fight if you want to verify his desire and will to win.
Who will win?
The respected opinions above favor Bradley 5-3. When this fight was made, I made the line considerably lower, with PacMan -130 to -140. I think the world of Manny as a fighter, and his career has been nothing but amazing. I just don't know what he has left in the tank. I also question his motivation and if he's really "right" mentally. Based on these questions and being able to take +180 or higher, I like the value in Bradley and think he wins a comfortable decision.
ESPN Chalk Pick: Bradley +180 or higher.