Browns' Myles Garrett has high ankle sprain, out at least 2 weeks

— -- Cleveland Browns defensive end Myles Garrett has been diagnosed with a high ankle sprain and will miss at least two weeks, the team announced Thursday.

Garrett will then be re-evaluated, according to the team. High ankle sprains sometimes sideline players for four to six weeks.

The Browns play the Pittsburgh Steelers on Sunday, followed by the Baltimore Ravens in Week 2.

Garrett, the top overall pick in the 2017 draft, was hurt Wednesday during Cleveland's first full practice leading to the opener. The injury occurred during a team drill when Garrett was engaged with an offensive lineman and a teammate fell against the side of his lower leg. Garrett left the field soon after.

Garrett's loss is another blow for the beleaguered Browns, who went 1-15 last season and have had their share of costly injuries in recent years. Quarterbacks Robert Griffin III and Josh McCown were hurt early last season. Wide receiver Corey Coleman, a first-round pick, missed six games with a broken hand, and Cleveland lost both starting guards to torn foot ligaments.

This is the second time the 6-foot-4, 275-pound Garrett has been hurt as a pro. He sustained a lateral sprain to his left foot during minicamp while pressuring former Browns quarterback? Brock Osweiler. The injury was initially thought to be serious, but Garrett's foot was immobilized in a walking boot and he recovered in time for the start of training camp.

The Browns eased him into practices, but it wasn't long before Garrett was dazzling Cleveland's coaches and teammates with his speed and strength. Garrett also impressed with his work ethic, staying after practice to run wind sprints to build stamina.

Also Thursday, the Browns signed defensive end Tyrone Holmes off the practice squad, and waived offensive lineman? Zach Sterup.

Information from ESPN Browns reporter Pat McManamon and the Associated Press was used in this report.