Palmer was limited all week with a right shoulder injury -- his throwing shoulder -- and was ruled questionable on Friday's injury report.
"It's a little bit of a nerve thing and they're very finicky," Cardinals coach Bruce Arians said on Friday.
Backup quarterback Drew Stanton will get his first start -- and first game action -- since Dec. 19, 2010 when he was with Detroit, a stretch of 1,365 days. In Week 15 that season, he was 23-of-37 passing for 252 yards and a touchdown in a 23-20 win over Tampa Bay. Stanton also ran for 24 yards.
During the 2014 preseason, Stanton was 27-of-38 (71.1 percent) passing for 341 yards and three touchdowns.
Without Palmer, rookie Logan Thomas would be activated as the backup quarterback.