Thanksgiving is notorious for extra long lines at the airports and bumper-to-bumper traffic on the highway.
Here's a look at this year's Thanksgiving travel by the numbers:
The TSA anticipates the busiest travel days will be Wednesday, Nov. 27, and Sunday, Dec. 1. The TSA predicts its agents will screen 2.7 million passengers on Nov. 27 and 2.8 million passengers on Dec. 1.
The afternoon of Nov. 27 will be the worst time for drivers to hit the road, according to INRIX, a global transportation analytics company.
Trips could take up to four times longer than normal during that peak time, according to INRIX.
The National Safety Council estimates 417 people may be killed and another 47,500 may be seriously hurt in car accidents this Thanksgiving. That's down nearly 4% compared to last year, in line with the estimated drop in overall car crash fatalities in the country.
The National Safety Council urges drivers "to be particularly vigilant" at the start of the holiday period on Nov. 27.
Nearly one-third of those killed in car crashes last Thanksgiving involved a drunk driver with a blood alcohol content of .08 or higher, according to data from the National Highway Traffic Safety Administration.
Amtrak had its largest passenger count to date during last year's Thanksgiving week, with over 846,000 riders on its trains across the country. Amtrak carried over 160,000 customers just on the Sunday after Thanksgiving last year.
Amtrak does not release specific number estimates, but Amtrak expects to see this positive trend continue this Thanksgiving, according to a spokesperson.
Amtrak is preparing to accommodate the surge of holiday travelers with extra trains and capacity on several popular routes.
ABC News' Matthew Vann contributed to this report.