Chunks of hail the size of golf balls were reported Monday night in Texas, Louisiana and Mississippi.
On Tuesday, severe thunderstorms moved into Georgia, South Carolina and Florida. In Pembroke, Georgia, a woman was killed Tuesday evening when her mobile home was destroyed by a possible tornado.
Two confirmed tornadoes already touched down early Tuesday in Texas, including one in Johnson County, near the town of Joshua, where one person died.
There were 21 reported tornadoes from late Monday through Tuesday from Mississippi to South Carolina. One of the radar confirmed tornadoes caused some structure and tree damage near the town of Newton, Mississippi, and Highway I-20.
In addition, officials in Allendale, South Carolina, told Savannah, Georgia, ABC affiliate WJCL that three people were left with non-life-threatening injuries after a possible tornado.
Thousands are without power in Washington state as a major storm moved through the area, producing wind gusts near 81 mph.
As this storm system moves east, wind and snow alerts are issued from the Rockies into the Plains with high fire danger from Texas to South Dakota. Red flag warnings have been issued for the Plains where winds could gust up to 70 mph.
California’s first major heat wave of the season is expected soon; a heat advisory was issued for Los Angeles and San Diego with high wind alerts posted for the mountain areas.
The heat wave will begin Wednesday with highs in the lower to middle 90s.
ABC News' Will McDuffie contributed to this report.