Lee County, which encompasses Fort Myers, accounts for most of the fatalities.
The remnants of Ian are charging up the East Coast on Saturday after making landfall as a Category 1 hurricane in South Carolina on Friday afternoon.
The monster storm made its first U.S. landfall on Wednesday on Florida's west coast as a powerful Category 4 hurricane, shredding homes with ferocious winds topping 150 mph. Florida's death toll has climbed to at least 81, according to information from local officials.
Officials in Miami-Dade County suspended transit services at 1 a.m. ET on Wednesday, as Hurricane Ian approached Florida.
Florida’s most populous county halted its Metrobus, Metrorail, Metromover and Special Transportation Services until further notice, officials said in a news release.
-ABC News’ Ahmad Hemingway
Hurricane Ian is fast approaching Florida, and the time to leave is "now" if you're in an evacuation zone, Gov. Ron DeSantis said late Tuesday during a press conference.
"Your time to evacuate is coming to an end. You need to evacuate now. You're going to start feeling major impacts of this storm relatively soon," the governor said. "Now is the time to do it, and now is the time to act."
As of Tuesday night, about 8,000 people were without power in the southern part of Florida, officials said.
Conditions are expected to continue to deteriorate across central and south Florida, with landfall currently forecast sometime between Wednesday afternoon and early evening.
Elsewhere, a tropical storm warning is now in effect along the coast of Georgia and up to Charleston, S.C.
-ABC News' Darren Reynolds, Dan Peck
President Joe Biden spoke Tuesday night with Gov. Ron DeSantis ahead of Hurricane Ian's arrival "to discuss the steps the federal government is taking to help Florida prepare," White House press secretary Karine Jean-Pierre tweeted.
"The president and the governor committed to continued close coordination," Jean-Pierre wrote.
-ABC News' Mary Bruce
Cuba has lost power after Hurricane Ian made landfall on the island Tuesday, according to reports.
The country's Electric Union said it's working to restore service overnight to 11 million people, The Associated Press reported. The Cuban News Agency had initially reported there is no power.
There is "0 electricity generation" in the country, according to a National Electric System update. "This complicated condition is also associated with complex weather conditions that have affected the SEN infrastructure," the update said.
-ABC News' Mara Valdes, Darren Reynolds
