Kameela Russell, 41, who works as a test chairperson at Miami Norland Senior High School, was last seen by her family on Wednesday in Miami Gardens, the Miami Gardens Police Department said.
Russell, who is the mother of two daughters, ages six and 15, was supposed to pick up one of her children at a relative's house on Wednesday, but never arrived, ABC Miami affiliate WPLG reported.
"Kameela's family is incredibly worried about her and we @MDCPS are praying for her swift and safe return," Miami-Dade County Public Schools Superintendent Alberto Carvalho tweeted. "Please take a moment to look at her picture and call police if you have seen her."
Russell has worked in the school district since 2014, said John Schuster, a spokesman with the school district.
"This teacher's disappearance is of great concern to her family and to many educators and students throughout Miami-Dade County Public Schools who hope and pray for her safe return," Schuster told ABC News via email. "We are assisting police in every way possible as they search for her."
Miami Gardens authorities did not immediately provide more information on the case.
Russell was last seen driving a 2014 black Audi A6 with license plate HBQJ20, according to police.
Anyone with information is asked to call the Miami Gardens Police Department at 305-474-6473.