Several inches of snow are possible in New York City Friday night and up to six inches may fall in Connecticut and Rhode Island.
By the early morning the snow will be hitting Boston, potentially bringing six to eight inches.
Meanwhile, out West, California is bracing for another storm set to strike Friday night after seeing almost two feet of rain this week.
California Gov. Gavin Newsom has declared an emergency for five counties after the heavy rain flooded about 2,000 buildings, trapped residents in floodwaters and led to the death of at least one person, according to The Associated Press.
Some of the heaviest rain for California will begin Friday night and Saturday morning.
The storm will then move east and by Saturday afternoon and night, it'll be bringing heavy snow to Denver.
By Sunday morning heavy snow will reach Kansas City and St. Louis.
Then Sunday night and into Monday morning, the Northeast region will see another round of snowfall as the storm brings snow, ice and heavy rain from Washington, D.C., to Boston.