Learn 'How Not to Die'

Dec. 1, 2008 — -- Medical examiner Jan Garavaglia has penned a book that just may add years to your life. In "How Not to Die," the doctor gives instructions for identifying unintentional ways we hurt our bodies.

She draws from her years of experience and gives information on how to live better and smarter. Read an excerpt of the book below and check out the "GMA" library.

Chapter One

Doctor Dreads Taking It on the Jaw

I followed the infection underneath his breastbone like a trail of bread crumbs all the way up to his jaw. The trail teemed with pus, the army of white blood cells that had marched through the walls of blood vessels to fight invading microorganisms. I had never seen anything like it before. Bacteria had waged a protracted war with his body's immune system–and won. I wondered how fifty-year-old Victor Baca could have developed such a virulent infection.

Ten days earlier, Victor had been in perfect health. Then he started complaining of back and shoulder pain and a sore throat. The symptoms kept him in bed and unable to go to work. Even so, he didn't seek medical attention. But as the pain worsened, Victor realized something was terribly wrong, and he called 911.

The dispatcher alerted an ambulance. Paramedics arrived, found him critically ill, and went to work immediately. Despite their aggressive intervention, including cardiopulmonary resuscitation (CPR), Victor slipped away, causes unknown. As I often do in cases involving unusual infections, after the autopsy I consulted Dr. Mark Wallace, an infectious disease specialist and an internal medicine physician, who also happens to be my husband. An infectious disease specialist tracks down bacteria and viruses, decodes their defenses and their weaknesses, and figures out what will kill them. Mark believed–and I concurred–that all the evidence proved that a bacterial infection had originated in Victor's mouth, shockingly, from the most ordinary of health problems: a common dental infection.

This infection probably migrated from a decayed tooth into the surrounding bone and tissue in his jaw and caused an abscess, a cavity containing pus surrounded by inflamed tissue. Many of us have probably had an abscess at one time or another. They can show up externally (in the gums or in a hair follicle) or internally (in an organ), and some types are more severe than others. Once a pocket of pus breaks through the thin bone surrounding the tooth sockets, bacteria can spread through the tissue planes of the neck and into the chest.

By the time Victor sought medical attention, bacteria had likely reached his bloodstream and caused multisystem organ failure. This infection was the source of all his pain–and the cause of his death. Before penicillin was discovered in 1928, bacterial infections like Victor's were the leading cause of death in the United States.

Today, due to widespread use of antibiotics, head and neck infections rarely kill, unless you have no access to, or reject, basic medical or dental care. For some unknown reason, Victor decided not to see a doctor, even as the unchecked infection spread to his chest and the pain became excruciating. What began as a run-of-the-mill oral infection became a fight for survival.

Eventually, Victor's organs ceased functioning, and he died. The tragedy was compounded by the fact that Victor's death could easily have been prevented. A routine course of antibiotics provided in a timely manner would have stopped the infection in its tracks.

Checked Out

As with the case of Victor Baca, I've seen firsthand the terrible complications that can arise when people don't go to the doctor, ignore a physician's advice, or decide to take medical matters into their own hands.

Another example from my case files is that of Kim Atani, age forty-eight. She was a woman who could have lived a long, normal life had she received proper medical care. Kim, who was blind, and her husband, Simon, were living in their Orlando home when Simon found her collapsed on the bedroom floor.

He called 911, and Kim was rushed to the hospital, where she later died. Her body was sent to my morgue to be autopsied.

Some of the most important information any physician–forensic pathologists included–can have is a medical history. But Kim arrived at the morgue without any medical records. I had to rely solely on observation to figure out why she died.

Clearly, something terrible had been happening. Her teeth were fractured at the gum line. She was also covered with bedsores, oozing craterlike wounds that can become seriously infected.

Medically known as "decubitus ulcers," bedsores develop quickly as tissue dies when blood flow is impaired by the continuous pressure of body weight on the soft tissues sandwiched between bone and a firm surface.

There was also gangrene, or dead tissue, which appeared as large, black, shriveled areas across her left foot. Gangrene is caused by progressive loss of blood to an area, and there are two types: wet and dry. Both are caused by poor blood flow, but in wet gangrene, the tissue is also infected with bacteria. Kim had wet gangrene.

Gangrene is often associated with advanced cases of diabetes. I dissected Kim's wet gangrene and discovered that the infection had burrowed down to her bone. If discovered in time, a limb so acutely diseased would have been amputated to prevent the spread of a life-threatening infection. With my scalpel, I made the standard Y incision, a deep cut from shoulder to shoulder across the chest, followed by a straight line down to the pubic bone. I then opened the torso like you'd open a jacket or sport coat.

Ribs were cut so I could gain access to the organs, which are removed, weighed, and dissected during the autopsy. After opening her up, I could see that her body harbored several other possible killers.

Her kidneys and liver were damaged, and her coronary arteries were more than 95 percent blocked. These findings were pieces of the puzzle that, along with her blindness, periodontal disease, and gangrene, began to fit a pattern.

It appeared to me that Kim Atani had been suffering from long-standing untreated diabetes. Diabetes is a metabolic disorder. Its hallmark is a failure to metabolize glucose, or blood sugar, carried by the bloodstream to fuel every part of the body. The failure is caused by problems with the hormone insulin.

Either the body doesn't make any (or enough) insulin, or cells don't respond to insulin properly. In either situation, glucose is unable to enter cells. It starts amassing in the bloodstream, where it can reach concentrations over ten times the normal level.

Over time, elevated glucose causes widespread organ damage, like that which I observed in Kim Atani. To confirm that Kim had diabetes, I would need to know her blood sugar levels. Testing for blood sugar is easy to do when you're living–blood is drawn and checked for its glucose concentration–but it's more complicated when you're dead.

After you die, your blood sugar begins to drop continuously toward zero. I can't even test for glucose levels in the blood because the blood breaks down right after death and interferes with testing. But I can test for glucose by using eye fluid drawn into a syringe–a procedure that can make you shudder if you've never seen it before. Each adult human eye contains about one-fifth of a teaspoon of jellylike fluid called vitreous humor. This fluid is very reliable for testing because it is isolated and protected, and therefore less subject to contamination or cell breakdown. I collected eye fluid from Kim's eyes and sent it to our toxicology lab. Glucose levels in the eye decrease after death, too, so a finding of elevated glucose would strongly indicate diabetes. Sure enough, when the toxicology report came back, it revealed that Kim's eye-fluid glucose was 378–massively elevated for a postmortem level.

Once I put all the facts of the case together and reviewed her tissues under a microscope, it was clear to me that over time, elevated glucose had caused widespread organ disease. It not only left Kim blind but it also caused a loss of sensation in her extremities and impaired her blood flow. Gangrene set in and allowed a deadly infection to take hold. The infection invaded her bloodstream, causing sepsis–an often fatal condition. Sepsis takes its name from the Greek word meaning "to putrefy." Known for generations as "blood poisoning," it generally means bacteria have breached the natural barriers of the skin and organs to enter the bloodstream.

Once there, they produce an overwhelming infection, the biological equivalent of tossing a grenade into your body. Blood pressure drops, vessels leak, and the lungs and kidneys fail. The result can be septic shock so severe that no amount of intravenous fluid or medication can reverse the condition. This is what happened to Kim Atani. Normally, a case like this would be closed, but I had to get to the bottom of why she had not sought medical care. Was it a case of negligence on the part of her husband, Simon? Could his inaction have contributed to her untimely death? If it was found that he had acted negligently, charges could be brought against him. I called Simon and told him that his wife had had diabetes. He was in denial about it, but more from ignorance about the disease than anything else. I pointedly asked why she didn't seek medical care and why he didn't seek medical care for her. He told me that his wife had had some bad experiences with doctors, that she refused to see one, and that she hated the medical establishment.

There was nothing he could do to get Kim to see a doctor, and so he vowed that he would do what he could to take care of her. In the end, and after confirming her fear of the medical system, I believed him. He was sincere and really cared about his wife. Many people make choices that ultimately lead to their demise, and at autopsy, my findings reflect this. As a medical examiner, I'm one of the few people given permission to look behind the curtain of someone's life, and what I observe is often senseless and tragic. I don't judge how people live, but I will say this: Not going to the doctor when you have a major health issue is your decision, but missing needed care might mean I'll be the doctor you'll eventually visit. Kim Atani and Victor Baca suffered not only from deadly but treatable illnesses; they also may have suffered from latrophobia or odontophobia.

These are medical terms that describe a fear of doctors or dentists, respectively, in which people put off getting medical attention, making excuse after excuse, until sometimes it's too late. Why do we fear doctors? I think one of the big reasons is that we're filled with dread that some serious problem might be found and we're afraid of hearing bad news. It's scary to be a patient. It's even scary for me to be a patient! Though we like to think we'll live forever, we're all here temporarily. Seeing a doctor brings us face-to-face with our own mortality. There are other reasons we avoid seeing a doctor. Maybe you don't think your symptoms are important. Maybe you're concerned about wasting a doctor's time. Or maybe you don't want to spend the money because you're uninsured. I can't tell you how many people I've autopsied because they didn't want to incur a medical bill. Or maybe you're a man.

Men in this country are much less likely to see a doctor than women are. Their reluctance may be one reason why the life expectancy of men is eight years shorter than that of women. Men repress pain, ignore symptoms, and deny sickness, in part to demonstrate their manhood. Society conditions men to "tough out" illness. They don't want to feel like wimps or go to the doctor for nothing. If a man does see a doctor, it's often because a woman in his life has made him go.

No one likes to get sick. It means that you can't do the things you enjoy or the things you live for. When you're sick, you don't feel like doing much of anything, except lying in bed. You might get better on your own, but then again, you might not. If you stay sick long enough, sooner or later you'll have to go to the doctor, whether you want to or not.

Wanted: A Great Doctor

If you're afraid of doctors, one of the best ways to get over your fear is to be under the care of one you like and trust. To find that kind of doctor takes a bit of sleuthing. Here's what I do: I look for a doctor who is geographically convenient, and I won't go to any doctor who is not board certified in his or her specialty or subspecialty.

Board certification means that a doctor has had extra training after medical school and internship in an approved training program to become an expert in a field of medicine such as family practice, internal medicine, or gynecology, then has passed a rigorous qualifying examination ("the boards"). Personality is important to me, too, so I ask around to get a feel for what a doctor is like. Nurses are a great resource, since they're the ones who work with doctors day to day and see how they treat patients. I also ask friends, family, coworkers, and colleagues.

Another good source is the website of the American Medical Association (www.ama-assn.org) with its DoctorFinder link. It gives you basic professional information on virtually every licensed physician in the United States. Of course, if you belong to a managed health-care plan, your choices are limited to doctors who are a part of that plan. I also want a doctor who treats me with respect and doesn't sugarcoat things. What you need most is good communication. You end up telling a doctor a lot of intimate details about your life.

If you feel uncomfortable doing so, that's your signal to find another one. Here are ten questions to ask when choosing a new doctor: 1.Are you board certified in your specialty? 2.What type of health insurance do you take? (If applicable, find out if the doctor accepts Medicare.) 3.How frequently do you see patients who have the same health problems as I have? 4.Do you refer patients to other doctors for special problems as needed? 5.Will I need to go to another location for blood tests or are lab tests done in your office? 6.If yours is a group practice, who are the other doctors and what are their specialties? 7.Who sees patients for you if you are out of town or not available? 8.Which hospitals do you use? Will you take care of me in the hospital if I'm admitted? If not, who will? (Make sure you're comfortable being treated at one of these institutions, should the need arise.) 9.How far in advance do I need to make an appointment to see you? 10.If I've got a problem (say a drug reaction or a treatment side effect) can I speak to you or your covering physician within a reasonable time frame? The M.D. or the M.E.?: When to See Your Doctor It's not a good idea to rush off to the doctor for every little ache and pain, but many symptoms are signs that the situation could be serious. If you try to outlast your medical problems, you may be making more trips to a doctor in the long run or, worse yet, a trip to the morgue. Here's what happened when one of my patients passed his symptoms off as little more than the flu.

Excerpt from: HOW NOT TO DIE Surprising Lessons on Living Longer, Safer, and Healthier from America's Favorite Medical Examiner, Dr. G, Jan Garvaglia, M.D.

ISBN 978-0-307-40914-0

Copyright © 2008 by Atlas Media Corp. and Jan Garavaglia, M.D.