Former Baltimore health commissioner Dr. Leana Wen said in an interview Monday hosted by the Bipartisan Policy Center that her family is rapid-testing on Thanksgiving because they're gathering indoors with multiple families and have young, unvaccinated children.

She said it was reasonable for families with immunocompromised members to continue to take precautions, like rapid test and gather outdoors.

"A family in which everybody is generally healthy and fully vaccinated might take very different types of risks than a family with unvaccinated young kids or elderly, immunocompromised family members," she said.

Dr. Jerome Adams, former Surgeon General under President Donald Trump, said to make sure all relatives are vaccinated and that no one has cold symptoms.

"Even if you're vaccinated, if you're coughing, if you're sneezing, if you've got symptoms, you still could be spreading the virus," he said.

Looking to the future, Dr. Anthony Fauci said, "If we can get most of the people who are eligible to be boosted, boostered, we can go a long way to make in 2022 much more of a normal year than what we've seen in 2021."

-ABC News' Cheyenne Haslett

The National Institutes of Health is starting a study to track the impact of COVID-19 infections in children, enrolling its first participant at the NIH's Clinical Center in Bethesda, Maryland.

The idea of “long COVID,” or long-term health impacts, is of concern in children, and is one of the reasons doctors strongly encourage pediatric vaccination. Six million children in the U.S. have had COVID-19, and many "experienced significant acute and long-term effects," the NIH said.

The study will track up to 1,000 children and young adults between 3 and 21 years old who previously tested positive for COVID-19 and evaluate the impact on their physical and mental health over three years.

The study will also try to determine risk factors for complications. It will evaluate the long-term immune responses to the disease, screen for genetic factors that may affect how children respond to COVID-19 infection and determine whether immunological factors influence long-term outcomes.

-ABC News' Eric M. Strauss

Dr. Anthony Fauci said vaccinated family members "can feel good about enjoying a typical Thanksgiving, Christmas," in an interview Monday hosted by the Bipartisan Policy Center.

But Fauci warned that cases are still high, so people should wear masks when they're in groups of people in indoor settings.

"We are not going to be going through this indefinitely," Fauci said. "How quickly we get to the end depends on us: how well we vaccinate, how well we get boosted and how well we do the kinds of things to protect ourselves."

-ABC News' Cheyenne Haslett

The daily case average in the U.S. now stands at 78,500 – a 23% jump over the last 2.5 weeks, according to federal data

Twenty-one states have seen an uptick in daily cases of 10% or more over the last two weeks: Arizona, Arkansas, Connecticut, Illinois, Indiana, Iowa, Kansas, Massachusetts, Michigan, Minnesota, Missouri, Nebraska, Nevada, New Hampshire, New Mexico, New York, Ohio, Pennsylvania, Rhode Island, Vermont and Wisconsin.

Last week marked the first national increase in hospitalizations in nearly 10 weeks. There are now more than 47,000 patients with COVID-19 in hospitals -- up by about 2,000 patients since last Monday, according to federal data.

-ABC News' Arielle Mitropoulos