Mayo Clinic said it will lay off about 1% of its staff for failing to get at least one dose of the COVID-19 vaccine by a company deadline.

"While Mayo Clinic is saddened to lose valuable employees, we need to take all steps necessary to keep our patients, workforce, visitors and communities safe. If individuals released from employment choose to get vaccinated at a later date, the opportunity exists for them to apply and return to Mayo Clinic for future job openings," Mayo Clinic said in a statement to ABC.

Last October, Mayo Clinic had set a Jan. 3 deadline for all employees to get at least their first vaccine dose or face dismissal.

The health care organization said the number of staffers being let go was "comparable to what other health care organizations have experienced in implementing similar vaccine requirement programs."

Mayo Clinic employs about 73,000 people, according to its website.

The FDA is warning people not to swab their throats as part of an at-home COVID-19 test.

In a statement obtained by ABC News, the FDA said that is not how the tests were designed and it could pose a safety concern.

"The FDA advises that COVID-19 tests should be used as authorized, including following their instructions for use regarding obtaining the sample for testing," the statement said.

Social media posts promoting at-home COVID-19 rapid test swabbing techniques claim that throat swabs collect a better sample. However, this hasn't been proven for currently authorized tests.

- ABC News' Sony Salzman

President Joe Biden announced Tuesday afternoon that he was doubling the federal government's purchases of Pfizer's COVID-19 antiviral pill, from 10 million to 20 million treatment courses.

"They’re a gamechanger and have the potential to dramatically alter the impact of COVID-19, the impact it's had on this country and our people,” Biden said.

He also warned that those who remain unvaccinated "will die" during the ongoing omicron surge.

“So there's no excuse, no excuse, for anyone being unvaccinated,” Biden said.

-ABC News' Ben Gittleson

Data released by the Centers for Disease Control and Prevention from the weekend shows that the U.S. is now averaging nearly half a million new cases a day.

About a year ago, the U.S. was reporting an average of about 216,000 new cases a day. However, compared to last winter, hospital admissions and daily deaths are notably lower.

Over the last week, the U.S. reported more than 3.4 million new cases -- roughly averaging out to nearly six Americans testing positive every second.

-ABC News' Arielle Mitropoulos

The American Medical Association, the nation’s largest association of physicians, has criticized the Centers for Disease Control and Prevention's new quarantine and isolation guidance for COVID-19, saying the recommendations "are risking further spread of the virus."

The CDC updated its guidelines on Dec. 27, saying asymptomatic people who test positive for COVID-19 should self-isolate for five days rather than 10.

"The American people should be able to count on the Centers for Disease Control and Prevention (CDC) for timely, accurate, clear guidance to protect themselves, their loved ones, and their communities. Instead, the new recommendations on quarantine and isolation are not only confusing, but are risking further spread of the virus," the American Medical Association's president, Dr. Gerald E. Harmon, said in a statement Wednesday night.

Harmon referenced data cited by the CDC in its rationale for shortening the isolation period, which estimates 31% of people remain infectious five days after a positive COVID-19 test, suggesting that data proves thousands of Americans could return to their lives while still infected.

"With hundreds of thousands of new cases daily and more than a million positive reported cases on January 3, tens of thousands -- potentially hundreds of thousands of people -- could return to work and school infectious if they follow the CDC’s new guidance on ending isolation after five days without a negative test," Harmon said. "Physicians are concerned that these recommendations put our patients at risk and could further overwhelm our health care system."

Harmon said a negative COVID-19 test should be required for ending isolation after a positive test, as reentering society without knowing whether an individual is still positive ultimately risks further transmission of the virus.

Although test availability remains an issue nationwide, Harmon also called on the Biden administration to ramp up production and distribution of tests, adding that "a dearth of tests at the moment does not justify omitting a testing requirement to exit a now shortened isolation."

-ABC News' Arielle Mitropoulos