HHS Secretary Alex Azar told "Good Morning America" that vaccinations could come Monday or Tuesday.

He said the Pfizer vaccine will be approved, they are just working out the details and finalizing the fact sheet on allergy warnings.

"We weren't counting on it in terms of getting to the projections that you and I have talked about about having enough vaccine for the second quarter," he said. "The Sanofi vaccine could be an important additional technology for later rounds of vaccination as one goes forward later in 2021."

Azar also said the Food and Drug Administration will proceed with the emergency use authorization for the Pfizer-BioNTech vaccine.

He said 20 million Americans will be vaccinated this month, up to 50 million total in January and the U.S. believes "we could have 100 million vaccinations in arm by the end of February."

Los Angeles Mayor Eric Garcetti shared "astounding" COVID-19 figures in a press briefing Thursday.

"In Los Angeles, someone is dying of COVID-19 every 20 minutes," the mayor said, as he reported that there were 74 new deaths from the virus in the county.

Los Angeles County reported a record 12,819 new COVID-19 cases, surpassing Sunday's record of 10,528. Cases have increased 1,000% in the past month-and-a-half, the mayor said.

Intensive care unit bed capacity has also dropped to 7.7%, he said.

"Today's COVID-19 data from LA County is the most devastating since the start of this pandemic," Garcetti said.

The mayor said there is a "light at the end of the tunnel." LA County could begin distributing vaccines early next week if one is authorized soon, he said.

The county could receive up to 83,000 doses in the next couple of days, and as many as 500,000 doses by the end of December, he said.

"I urge all Angelinos to get vaccinated as soon as they qualify," Garcetti said. "The end of this pandemic is finally, finally in sight."

-ABC News' Michelle Mendez contributed to this report.

The number of COVID-19 deaths in the U.S. increased dramatically in the past week, according to an internal memo from the U.S. Department of Health and Human Services obtained by ABC News Thursday night.

There were 16,237 deaths recorded from Dec. 4-10, marking a 44.3% increase in new deaths compared with the previous seven-day period, the memo said.

There were 1,449,322 new cases confirmed during that period -- a 26.9% increase week-over-week, according to the memo.

Across the country, 30% of hospitals have more than 80% of their intensive care unit beds filled, and 31% of ventilators in use are occupied by COVID-19 patients, HHS said.

Several states are seeing hospital strain.

COVID-19 hospitalizations in Nevada doubled from mid-October to mid-November, and projections show hospital capacity being surpassed in the next 30 days, HHS said.

In Pennsylvania, the seven-day hospitalization rate hit a new four-month peak on Dec. 6, and officials warned that hospitals will be overwhelmed if residents do not take precautions, the memo said.

-ABC News' Josh Margolin

The U.S. had its "worst week yet" during the pandemic in terms of COVID-19 deaths, according to an analysis by the COVID Tracking Project.

The seven-day average of reported deaths per day surpassed 2,000 this week for the first time since the spring. As of Dec. 9, that number was 2,281, a new record.

New COVID-19 deaths also set a record high this week, with 3,088 reported on Thursday.

As the number of new cases and current hospitalizations continue to climb, "the worst is yet to come," the COVID Tracking Project warned.

"Given the rapid increase in the number of new cases, we expect the metrics for hospitalizations and deaths to continue to rise in the coming weeks -- especially if in-person gatherings over Thanksgiving led to increased spread of the novel coronavirus, as public health experts warned," it said.

U.S. President-elect Joe Biden on Monday announced key nominations and appointments of his health team, a slate of experts and public officials who will lead his administration's response to the coronavirus pandemic.

"This trusted and accomplished team of leaders will bring the highest level of integrity, scientific rigor and crisis-management experience to one of the toughest challenges America has ever faced -- getting the pandemic under control so that the American people can get back to work, back to their lives and back to their loved ones," Biden said in a statement. "This team of world-class medical experts and public servants will be ready on day one to mobilize every resource of the federal government to expand testing and masking, oversee the safe, equitable and free distribution of treatments and vaccines, reopen schools and businesses safely, lower prescription drug and other health costs and expand affordable health care to all Americans, and rally the country and restore the belief that there is nothing beyond America's capacity if we do it together."

California Attorney General Xavier Beccera is nominated to serve as the Secretary of Health and Human Services.

Dr. Vivek Muthy, a physician and research scientist, is nominated to be the Surgeon General, a role he served during the Obama administration.

Dr. Rochelle Walensky, an expert on virus testing, prevention and treatment, is nominated to serve as director of the Centers for Disease Control and Prevention.

Dr. Marcella Nunez-Smith, an expert on health care disparities, will serve as the COVID-19 Equity Task Force Chair.

As Biden said last week, Dr. Anthony Fauci will stay on in his current role as director of the National Institute of Allergy and Infectious Diseases. Fauci will also serve as Biden's chief medical adviser on COVID-19.

Jeff Zients, co-chair of Biden's transition team who led the Obama administration's National Economic Council, will serve as coordinator of the COVID-19 Response as well as counselor to the president.

Natalie Quillian, a national security expert, will serve as deputy coordinator of the COVID-19 response.

ABC News' John Verhovek contributed to this report.