The U.S. is forecast to have almost 500,000 COVID-19 deaths by mid-February, incoming CDC Director Dr. Rochelle Walensky said on CBS’ "Face the Nation" Sunday morning.

She added, "That doesn't speak to the tens of thousands of people who are living with a yet uncharacterized syndrome after they've recovered."

Walensky, who was appointed by the Biden administration, believes that 100 million more doses of the vaccine will be available within the next 100 days.

"That is what the president-elect has promised," she said. “It will be a hefty lift, but we have it in us to do that.”

ABC News’ Brian Hartman contributed to this report.

People seeking COVID-19 vaccines in Houston were sent away from Minute Maid Park after appointments were overbooked.

The Houston Health Department announced Saturday that it had run out of vaccines by 6 p.m. after it had administered 5,451 doses at the site, where the line wrapped around the building, ABC Houston station KTRK reported. Several people left without getting vaccinated.

Houston Health Department Stephen Williams said during a press conference Saturday he warned the mayor that there wouldn’t be enough doses to last the week.

The city received “a little” over 30,000 doses, Houston Mayor Sylvester Turner said in a statement.

-ABC News’ Ahmad Hemingway contributed to this report.

Prince William championed the effort of the NHS, the U.K.'s health agency, in delivering the COVID-19 vaccine in a video posted to Kensington Royal's Twitter account Saturday night.

The video included several health care professionals on a Zoom call, along with the Duke of Cambridge, talking about distributing and delivering the vaccine.

"This is because we have a world-leading NHS, this is because we have the right people, the right research and development here," William says in the video.

William also encourages people to get the vaccine when they are eligible, noting his "grandparents" -- Queen Elizabeth and Prince Philip -- got the vaccine already. The palace said last week that Elizabeth, 94, and Philip, 99, had gotten the vaccine.

"My grandparents have had the vaccine and I'm very proud of them for doing that," he says in the video. "So it's really important that everyone gets their vaccine."

Los Angeles County, the hardest hit region in the country right now, announced it has crossed 1 million confirmed cases of COVID-19 on Saturday.

The county has identified 1,003,923 cases since the start of the pandemic -- the first county in the country to cross the mark. Only four states outside of California have met that ignominious total. The county announced 253 new deaths and 14,669 new cases on Saturday.

There are currently 7,597 people hospitalized in LA County with COVID-19 -- down slightly from days earlier when the total crossed 7,900.

Also of concern, the county identified its first case of the so-called U.K. variant on Saturday. The case was discovered in a man who was recently in LA, but has since traveled to Oregon, where he is isolating, the health department said.

"The presence of the U.K. variant in Los Angeles County is troubling, as our healthcare system is already severely strained with more than 7,500 people currently hospitalized," said Dr. Barbara Ferrer, director of public health. "This more contagious variant makes it easier for infections to spread at worksites, at stores, and in our homes."

There had already been 40 cases of the variant, officially called the B.1.1.7 variant, detected in California.

President-elect Joe Biden laid out a five-point vaccination plan Friday that he promised would turn the public's "frustration into motivation" and meet his goal of getting 100 million shots into Americans' arms within his first 100 days in office.

The plan includes working with states to open up more priority groups for vaccination, mobilizing a larger workforce to administer vaccines and working directly with independent and chain pharmacies to distribute them. Biden's administration also plans to set up 100 federally funded vaccination centers in school gyms, sports stadiums and mobile clinics to help reach communities that have been hit hard by the virus.

"Equity is central to our COVID response," Biden said.

Scientists in Biden's administration, like the surgeon general, will speak directly to the American people, he added, and pledged to be transparent about "both the good news and the bad" when it came COVID-19 progress. "You’re entitled to know," he said.