There were 22,930 new cases in Italy on Monday and 630 additional deaths, the country's Civil Protection Agency reported.

Italy now has 1,431,795 total COVID-19 cases and 50,453 deaths.

-ABC News' Christine Theodorou

British Prime Minister Boris Johnson said Monday that a monthlong, nationwide lockdown in England will be lifted next week as scheduled.

Nonessential businesses and shops, including gyms and hair salons, will be allowed to reopen when the country returns to a regional tiered system of COVID-19 restrictions after Dec. 2.

"For the first time since this wretched virus took hold, we can see a route out of the pandemic," Johnson told members of Parliament, adding that breakthroughs in testing, treatments and vaccines should reduce the need for restrictions next year.

Unlike previous restrictions, the tiered measures will be a uniform set of rules and much tougher. The prime minister is expected to announced which parts of the county is in which tier on Thursday.

"I can't say that Christmas will be normal this year," Johnson said. "We all want some kind of Christmas; we need it, we certainly feel we deserve it. But what we don't want is to throw caution to the winds and allow the virus to flare up again, forcing us all back into lockdown."

ABC News' Christine Theodorou contributed to this report.

More than 3 million people went through airport security checkpoints across the United States between Friday and Sunday, despite public health guidance against traveling for the upcoming Thanksgiving holiday.

The Transportation Security Administration (TSA) screened 1,019,836 individuals on Friday and 984,369 on Saturday. But Sunday saw the most travelers, with TSA screening 1,047,934 people -- the highest since the coronavirus pandemic was declared in mid-March.

The previous pandemic record was set on Oct. 18, the Sunday after the long Columbus Day weekend, when TSA screened 1,031,505 individuals.

Last week, the U.S. Centers for Disease Control and Prevention said it is recommending that Americans do not travel for Thanksgiving.

"It's not a requirement, it's a recommendation for the American public to consider," Dr. Henry Walke, the CDC's COVID-19 incident manager, told reporters during a call on Nov. 19. "Right now, as we're seeing exponential growth in cases and the opportunity to translocate disease or infection from one part of the country to another leads to our recommendation to avoid travel at this time."

ABC News' Sam Sweeney contributed to this report.

U.S. Surgeon General Jerome Adams said the nation is "at a dire point" in its fight against the coronavirus pandemic, "by any measure."

"Cases, positivity, hospitalizations, deaths -- we are seeing more Americans negatively impacted than ever before. But I also want Americans to understand that we've never had more reason for hope, thanks to science," Adams told ABC News' Cecilia Vega in an interview Monday on "Good Morning America."

"We're going to have people -- the vulnerable -- start to be vaccinated in mere weeks," he added. "So I"m asking Americans, I'm begging you, hold on just a little bit longer, keep Thanksgiving and the celebrations small and smart this year."

Adams advised people to hold Thanksgiving and holiday celebrations outdoors if possible, to keep the gatherings small -- ideally less than 10 attendees -- and to prepare ahead of time.

"Make sure you're not going around out in public and exposing yourself to other people, especially now heading into these celebrations," he said.

When asked about the White House's controversial plans to hold holiday parties indoors, Adams said the public health guidelines "apply to everyone."

"We want everyone to understand that these holiday celebrations can be super-spreader events, so we want them to be smart and we want them to be as small as possible," he said. "These apply to the White House, they apply to the American people, they apply to everyone."

The actual number of people infected with the novel coronavirus in the United States reached nearly 53 million at the end of September, according to a model developed by scientists at the Centers for Disease Control and Prevention.

The scientists estimated the cumulative incidence of COVID-19 in the U.S. population by taking the laboratory-confirmed case counts that were reported nationally and adjusting them for sources of under-detection based on testing practices in inpatient and outpatient settings. Preliminary estimates using the model found that 2.4 million hospitalizations, 44.8 million symptomatic illnesses and 52.9 million total infections may have occurred through Sept. 30.

"This indicates that approximately 84% of the U.S. population has not yet been infected and thus most of the country remains at risk, despite already high rates of hospitalization," the scientists wrote in a report published in the Nov. 25 issue of the journal Clinical Infectious Diseases.

There were 6.9 million laboratory-confirmed cases of of domestically-acquired infections that were detected and reported nationally through Sept. 30. Since then, the CDC's tally has increased to nearly 12.5 million. Based on the model's ratio, the true estimated total would now be more than 95 million.