Nearly 22,000 positive COVID-19 test results were reported in New York state in the last 24 hours, according to Gov. Kathy Hochul's office -- breaking a single-day record set the day before.

The 21,908 positive COVID-19 test results are out of 290,930 results reported -- for a 7.53% positivity rate.

Demand for testing also continues to rise, with about 27,000 more people getting tested on Friday.

"This is not like the beginning of the pandemic. We are prepared for the winter surge because we have the tools at our disposal," Hochul said in a statement. "Getting vaccinated, getting the booster and wearing a mask are critical to avoiding getting seriously ill from COVID-19, so don't take a chance."

-ABC News' Joshua Hoyos

President Joe Biden will deliver remarks this Tuesday on the country's fight against COVID-19 and "announce new steps" the administration will take amid the growing spread of the omicron variant, White House officials said.

The president will address steps the administration is taking "to help communities in need of assistance, while also issuing a stark warning of what the winter will look like for Americans that choose to remain unvaccinated," White House press secretary Jen Psaki said on Twitter Saturday afternoon.

The speech will come as millions of Americans prepare to travel and gather for the holidays, and as concerns about the omicron variant continue in the U.S. and around the world.

-ABC News' Molly Nagle

An additional 10,059 confirmed cases of the omicron variant of COVID-19 have been reported across the U.K., according to the U.K. Health Security Agency's daily omicron overview on Saturday.

Confirmed omicron cases in the U.K. now total 24,968.

-ABC News' Rashid Haddou

A federal appeals court reinstated the Biden administration's nationwide workplace vaccine mandate Friday.

The Sixth Circuit Court of Appeals dissolved the stay issued by the Fifth Circuit last month on the rule, which would require employees at private companies with over 100 workers to get vaccinated or tested regularly.

The mandate "is an important step in curtailing the transmission of a deadly virus that has killed over 800,000 people in the United States, brought our healthcare system to its knees, forced businesses to shut down for months on end, and cost hundreds of thousands of workers their jobs," Judge Jane Stranch wrote in the opinion.

The rule, which was set to go into effect on Jan. 4, 2022, had been put on hold by the Fifth Circuit after it ruled that the Labor Department’s Occupational Safety and Health Administration didn’t have the legal authority to impose such a requirement on private businesses.

The Labor Department had previously said it won’t move forward with enforcing its workplace mandate until the matter was resolved in court.

Arkansas Attorney General Leslie Rutledge said Friday she plans to ask the U.S. Supreme Court to block the order.

-ABC News' Benjamin Siu and Anne Flaherty

Boston's historic baseball stadium Fenway Park, which transformed into a mass vaccination site last winter, is expected to reopen its doors as a booster shot location in January, Red Sox officials told ABC News.

The Red Sox are working with the city and the governor's office to finalize the plans, Red Sox spokeswoman Zineb Curran said.

-ABC News' Arielle Mitropoulos