California is reinstating an indoor mask mandate from Dec. 15 to Jan. 15.

Half of the state is already under a mask mandate per local rules, according to California Health and Human Services Secretary Mark Ghaly.

California is also tightening restrictions on unvaccinated people at large events. At events with more than 1,000 people, anyone who isn’t vaccinated must show proof of a negative antigen test within 24 hours or a negative PCR test within 48 hours.

State officials also recommend that travelers get tested three to five days before arriving in California.

-ABC News' Matt Fuhrman

Last week, another 164,000 children in the United States tested positive for COVID-19, up by 24% from the week prior, according to a report released Monday by the American Academy of Pediatrics and the Children’s Hospital Association.

COVID-19 cases among U.S. children are "extremely high," the organizations wrote in the report.

Last week the Northeast saw its highest number of pediatric cases since the onset of the pandemic, with nearly 40,000 new cases.

So far, 21 million children ages 5 to 17 nationwide -- about 39.6% -- have received at least one dose of a COVID-19 vaccine.

Severe illness due to COVID-19 remains "uncommon" among children, the organizations wrote in the report. But they continue to warn that there is an urgent need to collect more data on the long-term consequences of the pandemic on kids, including the physical, emotional and mental health impacts.

-ABC News' Arielle Mitropoulos

A total of 50 million COVID-19 cases have now been confirmed in the U.S., according to data from Johns Hopkins University.

The U.S. has reported more cases than any other nation in the world. The U.S. currently represents nearly one-fifth of the globe's total 270.5 million cases.

-ABC News' Arielle Mitropoulos

In the weeks following Thanksgiving, the COVID-19 resurgence in the U.S. has escalated rapidly.

The U.S. is averaging more than 118,000 new cases each day -- up by about 41.8% in the last two weeks and up nearly 85% since late October, according to federal data.

Six states with some of the nation's highest vaccination rates are also among the states with the highest new case rates: New Hampshire, Vermont, Massachusetts, Maine, Rhode Island and New York. Experts say cases could be rising in the Northeast partially due to people heading inside in the cold weather.

Daily COVID-19-related hospital admissions increased by 14.4% in the last week and jumped by 48% in the last month, according to federal data.

Pediatric admissions are up by 23.8% in the last week.

-ABC News' Arielle Mitropoulos

A journalist traveling alongside U.S. Secretary of State Antony Blinken on his visit to Southeast Asia has tested positive for COVID-19 in Malaysia, according to U.S. Department of State spokesperson Ned Price.

Meanwhile, Blinken and his senior staff all tested negative for COVID-19 upon arrival in Kuala Lumpur on Tuesday night. The member of the traveling press pool who tested positive had last tested negative in Indonesia's capital, their previous stop, on Tuesday.

"The individual who tested positive will remain in isolation," Price said in a statement Wednesday, "and we will continue to adhere to and go beyond CDC guidance, including with our rigorous testing protocol, for the remaining traveling party."

Blinken has canceled a scheduled trip to Thailand "out of an abundance of caution" and will return home to the United States, according to Price.

"The Secretary expressed his deep regret to the Foreign Minister that he would not be able to visit Bangkok this week," Price said. "He explained that, in order to mitigate the risk of the spread of COVID-19 and to prioritize the health and safety of the U.S. traveling party and those they would otherwise come into contact with, the Secretary would be returning to Washington, D.C. out of an abundance of caution."

"The Secretary extended an invitation for the Foreign Minister to visit Washington, D.C. at the earliest opportunity and noted that he looked forward to traveling to Thailand as soon as possible," Price added. "They affirmed that they would use the upcoming engagements to further deepen the U.S.-Thai alliance."

The U.S. Embassy in Malaysia confirmed that the infected individual "was not involved and has not participated in any of Secretary Blinken's program in Kuala Lumpur."

"The sole member of the traveling party who tested positive is observing all requirements of the Ministry of Health," the embassy said in a statement Wednesday. "We confirm all other members of the party tested negative for COVID-19 upon arrival in Malaysia."

Blinken was in Indonesia on Tuesday, and the U.S. Embassy in Jakarta confirmed that no members of the traveling party tested positive for COVID-19.

All members of the U.S. delegation are required to be vaccinated against COVID-19 and undergo regular testing on trips.

-ABC News' Conor Finnegan