A federal judge in New York has again declined to impose a preliminary injunction on the city’s COVID-19 vaccine mandate for public school employees.

The public school employees have said they have religious objections to the COVID-19 vaccine. The U.S. District Court for the Southern District of New York previously ordered a citywide panel to reconsider their requests for religious accommodation. Most of the plaintiffs were denied a second time and sought the injunction to prevent their termination.

In an order filed Tuesday, Judge Valerie Caproni found New York City's vaccine mandate to be rational, saying: "The Court has no facts before it on which it could conclude that the Citywide Panel’s process was irrational in any way or infected with hostility to religion."

The decision comes a week after the U.S. Supreme Court declined to take up a petition from health care workers who opposed New York state's vaccine mandate on religious grounds. As long as mandates are generally applied and do not single out a particular religion, the courts -- at all levels -- have allowed them to stand.

-ABC News' Aaron Katersky

An 83% surge in newly confirmed cases of COVID-19 during the past week in Africa, driven by the delta and omicron variants, is causing fewer deaths than previous surges, the World Health Organization said Tuesday.

But the WHO cautioned that more waves of COVID-19 infections could be building as updated forecasts warn Africa, the world's second-largest and second-most-populous continent, may not reach 70% vaccine coverage until late 2024.

Africa recorded more than 196,000 new cases for the week ending on Dec. 12, an increase of around 107,000 from the previous week, bringing the cumulative count since the pandemic began to 8.9 million cases, according to the WHO. The number of new cases is currently doubling every five days, the shortest reported this year. While the speed of the spread is fast, the WHO said, deaths remain low and even dropped by 19% last week compared with the previous week.

Africa is currently in its fourth wave of the pandemic, during which there were a little over 3,000 deaths reported in the first three weeks. About half as many cases were reported in the same time frame during the continent's third wave, which was fueled by the highly contagious delta variant, according to the WHO.

The WHO said this spike in infections coupled with low hospitalizations is particularly evident in South Africa, which saw a 66% rise in new cases last week compared with the previous seven days. While hospital admissions have jumped by 65% in the past week, the bed occupancy rate for intensive care units remains low at 7.5%, with 14% of the hospitalized patients receiving supplemental oxygen. Though the number of deaths also remain low, the WHO warned that this pattern may change in the coming weeks.

"We are cautiously optimistic that deaths and severe illness will remain low in the current wave, but slow vaccine rollout in Africa means both will be much higher than they should be," Dr. Matshidiso Moeti, the WHO's regional director for Africa, said in a statement Tuesday. "We've known for quite some time now that new variants like Beta, Delta or Omicron could regularly emerge to spark new outbreaks globally, but vaccine-deprived regions like Africa will be especially vulnerable."

As of Tuesday, only 20 African countries had vaccinated at least 10% of their population -- the global target the WHO had set for September 2021. Only six African nations have hit the year-end target of fully vaccinating 40% of their population, while just two countries -- Mauritius and Seychelles -- have reached the 70% coverage seen as essential for controlling the pandemic. At the current pace, the WHO estimates that it will take until May 2022 before Africa as a whole reaches 40% coverage and August 2024 before it reaches 70%.

"In a world where Africa had the doses and support to vaccinate 70% of its population by the end of 2021—a level many wealthy countries have achieved—we probably would be seeing tens of thousands of fewer deaths from COVID-19 next year," Moeti said. "But we can still save many lives if we can accelerate the pace of vaccination in early 2022."

Pfizer's forthcoming COVID-19 treatment could be authorized for emergency use in the United States by the end of this year or early next year, pending the Food and Drug Administration's regulatory timeline, Pfizer CEO Albert Bourla told ABC News.

The pharmaceutical giant announced Tuesday that it has submitted promising new data to the FDA, including lab experiments showing its oral antiviral medicine, Paxlovid, will likely work against the omicron variant. And in updated clinical trial data, Pfizer found the treatment reduces the risk of being hospitalized or dying by 89% when taken within three days of being diagnosed with COVID-19, and 88% when taken within five days of being diagnosed among high-risk, unvaccinated patients.

"It is a game changer," Bourla told ABC News. "But at the same time, I want to emphasize that no one should use the existence of the pill as an excuse to avoid vaccination."

Bourla said the medicine could save thousands of lives.

"We did some calculations how many deaths or hospitalizations can be avoided based on the current U.S. mortality rates and the current U.S. hospitalization rates," he said. "On the back-of-the-envelope calculation, we estimate that 100,000 people if they take the pill, we will avoid 6,000 hospitalizations and 1,200 deaths approximately."

-ABC News' Sony Salzman

France is considering tightening restrictions for travelers arriving from the United Kingdom, where the omicron variant appears to be spreading swiftly.

"Regarding Britain, the current rule is to show a negative test less than 48 hours old in order to enter France," French government spokesman Gabriel Attal told France Info radio on Tuesday. "But we are always looking at means to tighten the framework, we are currently working on that and we should, I think, come to a conclusion in the coming days."

Dr. Anthony Fauci, the nation's leading expert on infectious diseases, warned Thursday that omicron will become the dominant variant of the novel coronavirus in the United States "very soon."

"It has an extraordinary ability to transmit efficiently and spread," Fauci, the chief medical advisor to U.S. President Joe Biden, told ABC News' George Stephanopoulos in an interview on "Good Morning America."

"It has what we call a doubling time of about three days and if you do the math on that, if you have just a couple of percentage of the isolates being omicron, very soon it's going to be the dominant variant," he explained. "We've seen that in South Africa, we're seeing it in the U.K. and I'm absolutely certain that's what we're going to be seeing here relatively soon."

Fauci, who is also the director of the National Institute of Allergy and Infectious Diseases, urged Americans to "absolutely" get vaccinated against COVID-19, if they haven't already, and to also receive a booster shot when they become eligible.

"At this point, we don't believe you need an omicron-specific boost," he added. "We just need to get the boost with what you got originally for the primary vaccination."