British Prime Minister Boris Johnson announced Wednesday his plans to lift all remaining pandemic-related restrictions in England in less than two weeks.

Addressing lawmakers in the United Kingdom's House of Commons, Johnson said he hopes to scrap England's COVID-19 restrictions as soon as Parliament returns from its upcoming recess on Feb. 21.

"I can tell the House today that it is my intention to return on the first day after the half-term recess to present our strategy for living with COVID," Johnson told lawmakers. "Provided the current encouraging trends in the data continue, it is my expectation that we will be able to end the last domestic restrictions, including the legal requirement to self-isolate if you test positive, a full month early."

Johnson first announced his plans to end all of the so-called Plan B measures last month, starting with mask mandates. He told lawmakers at the time that the legal requirement for people with COVID-19 to self-isolate would be allowed to expire when the regulations lapsed on March 24, but that the date could be brought forward.

Although Johnson is the U.K. prime minister, his government is only responsible for COVID-19 restrictions in England because public health legislation is devolved to national governments within the U.K., meaning that Scotland, Wales and Northern Ireland are responsible for their own pandemic-related policies.

The United States reported the highest number of newly confirmed COVID-19 cases and deaths from the disease last week out of any country in the world, according to a weekly epidemiological update released Tuesday by the World Health Organization.

More than 1.8 million new cases were reported in the U.S. during the week of Jan. 31 to Feb. 6, a 50% decrease compared to the previous week. Over 14,000 new fatalities were also reported, a 15% decrease, the WHO said.

France had the second-highest number of new cases with more than 1.7 million, a 26% decrease, while India had the second-highest number of new deaths with nearly 8,000, a 69% increase, according to the WHO.

Meanwhile, the global number of new cases during that same period decreased by 17% compared to the previous week, while fatalities increased by 7%, the WHO said.

Boston Mayor Michelle Wu outlined her plan to drop the city's proof of vaccine requirement at indoor businesses including bars, movie theaters and restaurants.

The city must have fewer than 200 COVID-19 hospitalizations a day, 95% of ICU beds need to be free and the community positivity rate must be below 5%, before the requirement is removed, she said.

"The fastest way to help ensure we are relieving pressure on hospital capacity and driving down community positivity is to keep closing gaps with vaccination and boosters," Wu said in a statement.

There are no immediate plans to end the city's mask mandate in schools, she added.

-ABC News' Arielle Mitropoulos

While California Gov. Gavin Newsom announced Monday that he will end the statewide mask mandate next week, Los Angeles County health officials said Tuesday they have no immediate plans to drop their mask mandate.

LA County Department of Health Director Dr. Barbara Ferrer told reporters the county's decision will be made based on dropping hospitalization numbers or vaccination approval for young children.

The mandate will be dropped when daily hospitalizations drop below 2,500 for seven consecutive days, according to Ferrer. Once this threshold is met, "masking will no longer be required while outdoors at outdoor mega events or an indoor outdoor spaces at childcare and K to 12 schools," Ferrer said.

Even if that threshold is not met, the mandate could be dropped eight weeks after vaccines are approved for children under 5. Pfizer submitted a request to the Food and Drug Administration to have its vaccine approved for children 6 months to 5 years old. A hearing is scheduled for Feb. 15.

Los Angeles County is the second-largest school district in the country, with over 600,000 students.

Pfizer said it has postponed its application to the FDA to expand the use of its COVID-19 vaccine for kids under 5.

Pfizer instead will continue with its study on the three-dose vaccine and seek authorization when that data is available.

"We believe additional information regarding the ongoing evaluation of a third dose should be considered as part of our decision-making for potential authorization," Pfizer said.

Dr. Peter Marks, the FDA’s vaccine chief, told reporters Friday, “We realized now, in data that came in very rapidly because of the large number of cases of omicron, that at this time, it makes sense for us to wait until we have the data from the evaluation of a third dose before taking action."

Marks acknowledged that the change was “late breaking” -- the FDA’s committee of independent advisers was scheduled to review and vote on authorizing the vaccine next week -- but said the job of the FDA was to “adjust” to new data amid an unpredictable virus.

“The data that we saw made us realize that we needed to see data from a third dose as in the ongoing trial in order to make the term determination that we could proceed with doing an authorization,” Marks said.

Pfizer has predicted it will be able to submit data on the third dose in early April.

-ABC News' Eric M. Strauss, Cheyenne Haslett