The U.S. is forecast to have almost 500,000 COVID-19 deaths by mid-February, incoming CDC Director Dr. Rochelle Walensky said on CBS’ "Face the Nation" Sunday morning.

She added, "That doesn't speak to the tens of thousands of people who are living with a yet uncharacterized syndrome after they've recovered."

Walensky, who was appointed by the Biden administration, believes that 100 million more doses of the vaccine will be available within the next 100 days.

"That is what the president-elect has promised," she said. “It will be a hefty lift, but we have it in us to do that.”

ABC News’ Brian Hartman contributed to this report.

People seeking COVID-19 vaccines in Houston were sent away from Minute Maid Park after appointments were overbooked.

The Houston Health Department announced Saturday that it had run out of vaccines by 6 p.m. after it had administered 5,451 doses at the site, where the line wrapped around the building, ABC Houston station KTRK reported. Several people left without getting vaccinated.

Houston Health Department Stephen Williams said during a press conference Saturday he warned the mayor that there wouldn’t be enough doses to last the week.

The city received “a little” over 30,000 doses, Houston Mayor Sylvester Turner said in a statement.

-ABC News’ Ahmad Hemingway contributed to this report.

Prince William championed the effort of the NHS, the U.K.'s health agency, in delivering the COVID-19 vaccine in a video posted to Kensington Royal's Twitter account Saturday night.

The video included several health care professionals on a Zoom call, along with the Duke of Cambridge, talking about distributing and delivering the vaccine.

"This is because we have a world-leading NHS, this is because we have the right people, the right research and development here," William says in the video.

William also encourages people to get the vaccine when they are eligible, noting his "grandparents" -- Queen Elizabeth and Prince Philip -- got the vaccine already. The palace said last week that Elizabeth, 94, and Philip, 99, had gotten the vaccine.

"My grandparents have had the vaccine and I'm very proud of them for doing that," he says in the video. "So it's really important that everyone gets their vaccine."

Los Angeles County, the hardest hit region in the country right now, announced it has crossed 1 million confirmed cases of COVID-19 on Saturday.

The county has identified 1,003,923 cases since the start of the pandemic -- the first county in the country to cross the mark. Only four states outside of California have met that ignominious total. The county announced 253 new deaths and 14,669 new cases on Saturday.

There are currently 7,597 people hospitalized in LA County with COVID-19 -- down slightly from days earlier when the total crossed 7,900.

Also of concern, the county identified its first case of the so-called U.K. variant on Saturday. The case was discovered in a man who was recently in LA, but has since traveled to Oregon, where he is isolating, the health department said.

"The presence of the U.K. variant in Los Angeles County is troubling, as our healthcare system is already severely strained with more than 7,500 people currently hospitalized," said Dr. Barbara Ferrer, director of public health. "This more contagious variant makes it easier for infections to spread at worksites, at stores, and in our homes."

There had already been 40 cases of the variant, officially called the B.1.1.7 variant, detected in California.

Weeks after video emerged of mostly maskless partygoers at U.S. President Donald Trump's Mar-a-Lago Club in Palm Beach, county officials are cracking down.

Palm Beach County sent a letter this week, acquired by ABC News, warning the club and saying officials had met with representatives from the club about violations. Masks are mandatory in the county in all businesses or establishments, and anywhere in public social distancing cannot be maintained. The mandate is currently in place through Jan. 20 -- the same day the county's most famous resident will be exiting the White House.

"Thank you for meeting with us last week to discuss the concerning allegations regarding the Mar a Lago New Year's Eve party and lack of facial coverings being worn during evening activities," the county wrote in the letter addressed to Bernd Lembcke, executive vice president and managing director of Mar-a-Lago Club.

"We recount that you provided masks for all party goers who attended the party and that you provided additional masks for those that walked from the reception area to the main dining ballroom," the letter continued. "Although you provided these important steps, it seemed that based on the video evidence, there was a breakdown in enforcement of the mask orders that led to almost the entire room of guests being without masks during the later evening activities."

The letter also includes a confirmation of the violation, which is a first-time warning, that lays out a fine of up to $15,000 for each potential future violation.

Trump has consistently downplayed wearing masks over the course of the entire pandemic. Despite telling people to wear masks on occasion at official briefings, he also mocked others for wearing them, including President-elect Joe Biden. Many supporters have decried mandates and openly flouted rules, including maskless Trump supporters who stormed the Capitol last week.

ABC News' Will Gretsky contributed to this report.