The Northeast and Midwest are seeing the largest jump in cases and hospitalizations, according to federal data.

Twenty-seven states have seen at least a 10% jump in daily cases over the last two weeks: Arizona, Arkansas, Connecticut, Delaware, Illinois, Indiana, Iowa, Kansas, Kentucky, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Nebraska, New Hampshire, New Mexico, New York, New York City, Ohio, Oklahoma, Pennsylvania, Rhode Island, South Dakota, Tennessee, Utah, Vermont and Wisconsin.

Eighteen states have seen at least a 10% increase in hospital admissions over the last week: Georgia, Hawaii, Illinois, Indiana, Kentucky, Maine, Massachusetts, Michigan, Minnesota, Nebraska, New Hampshire, New Jersey, New Mexico, New York, Ohio, South Dakota, Texas and Wisconsin.

-ABC News' Arielle Mitropoulos

Florida Gov. Ron DeSantis on Thursday signed legislation that prohibits private employer vaccine mandates and says employers that violate the ruling will be fined.

The legislation also states educational institutions can't require students to be vaccinated; school districts can't have face mask policies or quarantine healthy students; and families can "sue violating school districts."

"Nobody should lose their job due to heavy-handed COVID mandates," DeSantis, a Republican, said in a statement.

New York Gov. Kathy Hochul is calling on workers to head back to the office in the new year.

"How about this New Year's resolution: that in the days after New Year’s, that we say everybody back in the office. You can have a flex time, but we need you back, at least the majority of the week," Hochul told industry leaders at the Association for a Better New York breakfast.

Hochul also said she would be in Times Square on New Year's Eve.

Times Square is reopening this New Year's Eve after being closed last year due to the pandemic. Revelers must bring proof of full vaccination and a photo ID.

"I can't wait to put 2020 - 2021 behind us," the governor said.

-ABC News' Aaron Katersky

COVID-19 "is one of the top ten leading causes of death in children" and vaccines are a "safe and simple intervention" to significantly lower the risk of severe illness, emergency physician Dr. Leana Wen and professor of health policy and management at GW said at a National Press Foundation briefing Wednesday.

Dr. Sean O’Leary, vice chair of the committee on infectious diseases for the American Academy of Pediatrics, said he believes that the fear surrounding the vaccine is largely based on misinformation.

Both doctors also pointed to the problem of access to vaccines, with many Americans in rural areas living in “pharmacy deserts.”

“We should not assume that these people don’t want the vaccine. A lot of it is access,” Leary said.

Officials need to hold clinics in places like schools, Wen added.

-ABC News' Arielle Mitropoulos

For the second week in a row, the U.S. experienced an increase in its weekly number of pediatric COVID-19 cases.

Over the last week, more than 122,000 child cases were reported — an increase of about 22% from two weeks ago, according to a new report from the American Academy of Pediatrics (AAP) and the Children’s Hospital Association (CHA).

This marks the 14th consecutive week that child COVID-19 cases are above 100,000.

Prior to the recent increases, infections among children had been steadily dropping since the pandemic peak of 252,000 child cases, recorded over the span of a week in early September.

But now, COVID-19 cases among children remain "extremely high," the organizations wrote, and since the first week of September, there have been almost 1.6 million additional child cases.

Last week, children accounted for more than a quarter (27%) of reported weekly COVID-19 cases, though children under 18 make up just 22.2% of the U.S. population.

-ABC News’ Arielle Mitropoulos