In an interview with the podcast “In the Bubble,” Dr. Anthony Fauci told former White House adviser Andy Slavitt that he predicts three doses will become the standard dosing regimen for COVID-19 vaccines going forward.

Fauci cited new data from Israel that vaccine protection against hospitalization dropped in recent months from some 97% to 77% or 78%.

The vaccines still provide extraordinary protection, but the combination of the delta variant and waning immunity with time are causes for concern, he said.

Fauci added that that he thinks it will probably be the end of 2022 or early 2023 before much of the world is vaccinated.

-ABC News' Anne Flaherty

Kentucky is "quickly approaching that point" where hospitals will need to start rationing care, Gov. Andy Beshear warned on CNN.

Over two-thirds of Kentucky's hospitals have critical staffing shortages, the governor said. FEMA and National Guard teams have been called in and nursing students have been deployed across the state, he said.

"We've got one hospital in Morehead called St. Clair that's closed three operating rooms to expand ICU bed space," he said. "We had a hospital in Danville, Kentucky, that's not used to treating really sick patients, that had a morgue for two -- and had seven individuals pass away in their hospital over one weekend."

"We've set up tents outside Pikeville Medical Center to triage whether people really need to be in the hospital or not," Beshear continued. "We're in a very precarious situation."

-ABC News' Brian Hartman

All participants in this year's Macy’s Thanksgiving Day Parade must be vaccinated and wear face coverings, the department store announced Wednesday. Singers, dancers and musicians may be exempt from wearing face masks.

The number of participants will see a 10 to 20% cut this year and social distancing will be followed, Macy's added.

Last year, much of the parade was pre-taped due to the pandemic. There were no high school band performances and limited spectators on the street.

The marching band and other specialty group performances that were initially set to perform last year will get to participate in this Thanksgiving's parade, Macy's said.

The Supreme Court will resume in-person oral arguments on Oct. 4 for the first time since the pandemic began.

All arguments will be in person from Oct. 4 through the rest of the year. The courtroom will only have staff, counsel of cases on the docket and hard-pass court reporters there in person, with the court staying closed to the general public.

The court says it will continue to offer a real-time live audio feed of arguments.

-ABC News' Devin Dwyer

The daily death average in the U.S. has climbed to about 1,100, which is a 65.5% jump in the last month, according to federal data.

The daily case average in the U.S. is around 140,000, which is nearly four times higher than it was one year ago, according to federal data.

South Carolina and Kentucky have the highest case rate in the nation, followed by West Virginia, Wyoming, Alaska, Alabama, Georgia and Mississippi, according to federal data.

But some states are seeing progress. In Florida, daily cases are down by about 33% in the last two weeks.

-ABC News' Arielle Mitropoulos