A Florida school district that defied Gov. Ron DeSantis' ban on school mask mandates said Tuesday that two of its employees died from the virus last weekend.

Carlee Simon, the superintendent for the Alachua County Schools, said in a statement that the district "is experiencing this spike first-hand."

"Over the weekend two of our employees passed away from COVID," she said in a statement. "We've had 18 new cases in the last three days alone. More than 80 employees are now in quarantine, and that number is rising fast."

The school district, which includes which includes Gainesville, voted Tuesday night to issue a mask mandate for students and staff for the next two weeks. The mandate will be reevaluated on Aug. 17, Simon said.

The Hawaii State Department of Education announced that all middle and high school athletes, athletic staff and volunteers will need to be fully vaccinated by Sept. 24 in order to participate in activities.

The rule affects students who are eligible for the vaccines, meaning they must be over 12.

"This decision was not made lightly because we know the important role athletics play in a well-rounded education, but we cannot jeopardize the health and safety of our students and communities," interim Superintendent Keith Hayashi said in a statement.

The start of the athletic season was delayed to Sept. 24 due to the state's rising positivity rate, according to the department.

This is the first state to require vaccinations for its student athletes.

-ABC News' Bonnie McLean

Illinois Gov. JB Pritzker announced Wednesday that all pre-K through 12th grade schools and day cares must follow universal masking indoors regardless of vaccination status.

Pritzker said the state is facing a growing threat from the delta variant and noted that children under 12 aren't yet eligible for COVID-19 vaccines.

"Far too few school districts have chosen to follow the federal Centers for Disease Control and Prevention prescription for keeping students and staff safe," he said at a news conference. "Given the CDC’s strong recommendation, I had hoped that a state mask requirement in schools wouldn’t be necessary, but it is."

The latest delta surge is once again pushing hospital staffing to breaking points across the U.S.

In Alaska, Idaho, Oregon and Washington, some "facilities are experiencing substantial shortages of both clinical and support staff," according to a Department of Health and Human Services planning document obtained by ABC News Wednesday.

In hard-hit Missouri, many hospitals "don’t have the staff to support a surge without further modification to operational strategies," the document said.

At a Shreveport, Louisiana, hospital, where the number of COVID-19 patients are multiplying, nurse Melinda Hunt told ABC News, "To be honest, I probably cry most days at work. And I cry at home. I’m tired. I’ve been doing this a year and half. It feels like it’s never going to end."

Mississippi is facing "a phenomenal increase in daily reported cases of COVID, and this is entirely attributable to the delta variant, which is sweeping over Mississippi like a tsunami," state health officer Dr. Thomas Dobbs said Thursday.

Dobbs said 97% of new cases are among the unvaccinated, and that 89% of hospitalizations and 85% of deaths are unvaccinated.

Dobbs pleaded with the public to get vaccinated, stressing that the unvaccinated population is driving the current surge, but that vulnerable, vaccinated people are suffering the fallout.

"There is going to be some collateral damage, unfortunately, even folks who've done everything they can to protect themselves," Dobbs said.

"The minority of folks who are vaccinated and hospitalized are overrepresented by the older and those with weaker immune system, so we're seeing a pretty dramatic spillover effect from the transmission in the community to more vulnerable parts of our population," he said.

-ABC News' Soorin Kim