Five states have intensive care units over 90% full: Alabama (99.31%), Florida (91.63%), Georgia (91.03%), Mississippi (91.26%) and Texas (91.38%), according to federal data.

Nationally, about 75% of adult ICU beds are occupied.

Florida has the nation's highest case rate, followed by Louisiana, Mississippi, Arkansas, Alabama, Texas, Hawaii, Missouri, Georgia and Kentucky, according to federal data.

As of Tuesday morning, more than 88,000 Americans were hospitalized with COVID-19, marking the highest number since Feb. 1, according to federal data.

The U.S. is recording about 500 COVID-19 deaths per day, which is nearly a 131% jump in the last month.

-ABC News' Arielle Mitropoulos

COVID-19 cases among Kentucky children jumped 400% in the last month as a record number of kids have been admitted to hospitals, Gov. Andy Beshear announced Tuesday.

"Kentucky’s case numbers and positivity rate have continued to rise rapidly after record lows for the past year were recorded for both metrics in June," the governor's office said.

Kentucky's positivity rate stands at 12.4%.

As of Sunday, there were only 17 Kentucky counties where at least 50% of residents had at least one vaccine dose, the governor's office said.

Every state now has at least 50% of the eligible population (12 years and older) with at least one vaccine dose, White House COVID-19 data director Cyrus Shahpar tweeted.

Some states have over 80% of the eligible population with at least one dose, he added.

-ABC News' Alexandra Faul

Less than two months after the Food and Drug Administration granted emergency authorization for the treatment Actemra for severely sick COVID-19 patients, there are already global shortages due to an "unprecedented surge in worldwide demand," the manufacturer, Roche, said.

Actemra helps fight the inflammatory immune reaction some COVID-19 patients have with severe infection.

Roche said employees have been "working around the clock" to boost production and distribution.

"Despite all these efforts, the unfortunate reality is that due to the unprecedented surge in worldwide demand -- with US demand spiking to well-beyond 400% of pre-COVID levels over the last two weeks alone -- we will experience shortages of Actemra/RoActemra globally over the weeks and months ahead," Roche said. "This is due to global manufacturing capacity limits, raw material supply constraints, the complex, labour-intensive process of manufacturing biologics and the dynamically evolving nature of the pandemic."

The World Health Organization added Actemra to its list of COVID-19 treatments in July following FDA authorization.

-ABC News' Sasha Pezenik

Children's of Mississippi, the state's only pediatric hospital, reported a record number of patients Thursday.

There are 28 children, all unvaccinated, with confirmed or suspected cases of COVID-19, the highest since the start of the pandemic, the hospital said on Facebook. Among those, eight children are in the intensive care unit, including five not yet old enough to receive the vaccine, the hospital said.

"The best way to protect ALL of Mississippi's kids from COVID-19 is for everyone age 12 and up to get vaccinated," said the hospital, which is part of the University of Mississippi Medical Center in Jackson.

Nearly 43% of Mississippi residents ages 12 and up are fully vaccinated, according to CDC data, one of the lowest rates in the country.