Five states have intensive care units over 90% full: Alabama (99.31%), Florida (91.63%), Georgia (91.03%), Mississippi (91.26%) and Texas (91.38%), according to federal data.

Nationally, about 75% of adult ICU beds are occupied.

Florida has the nation's highest case rate, followed by Louisiana, Mississippi, Arkansas, Alabama, Texas, Hawaii, Missouri, Georgia and Kentucky, according to federal data.

As of Tuesday morning, more than 88,000 Americans were hospitalized with COVID-19, marking the highest number since Feb. 1, according to federal data.

The U.S. is recording about 500 COVID-19 deaths per day, which is nearly a 131% jump in the last month.

-ABC News' Arielle Mitropoulos

COVID-19 cases among Kentucky children jumped 400% in the last month as a record number of kids have been admitted to hospitals, Gov. Andy Beshear announced Tuesday.

"Kentucky’s case numbers and positivity rate have continued to rise rapidly after record lows for the past year were recorded for both metrics in June," the governor's office said.

Kentucky's positivity rate stands at 12.4%.

As of Sunday, there were only 17 Kentucky counties where at least 50% of residents had at least one vaccine dose, the governor's office said.

Every state now has at least 50% of the eligible population (12 years and older) with at least one vaccine dose, White House COVID-19 data director Cyrus Shahpar tweeted.

Some states have over 80% of the eligible population with at least one dose, he added.

-ABC News' Alexandra Faul

Less than two months after the Food and Drug Administration granted emergency authorization for the treatment Actemra for severely sick COVID-19 patients, there are already global shortages due to an "unprecedented surge in worldwide demand," the manufacturer, Roche, said.

Actemra helps fight the inflammatory immune reaction some COVID-19 patients have with severe infection.

Roche said employees have been "working around the clock" to boost production and distribution.

"Despite all these efforts, the unfortunate reality is that due to the unprecedented surge in worldwide demand -- with US demand spiking to well-beyond 400% of pre-COVID levels over the last two weeks alone -- we will experience shortages of Actemra/RoActemra globally over the weeks and months ahead," Roche said. "This is due to global manufacturing capacity limits, raw material supply constraints, the complex, labour-intensive process of manufacturing biologics and the dynamically evolving nature of the pandemic."

The World Health Organization added Actemra to its list of COVID-19 treatments in July following FDA authorization.

-ABC News' Sasha Pezenik

A new CDC analysis found that Pfizer and Moderna vaccine efficacy dropped "significantly" among nursing home residents from March to July, as the delta variant became the predominant strain in the United States.

Researchers analyzed weekly reports from thousands of nursing home facilities in the U.S. and found that mRNA vaccines were roughly 75% effective against preventing any infection in late winter/early spring of 2021, early in the mass vaccination rollout and prior to the emergence of the delta variant. By summer of this year, effectiveness against any infection had dropped to 53%.

Crucially, this doesn't mean vaccines aren't working for nursing home residents, but the significant drop in effectiveness from March to July may support the use of booster doses for them, according to the CDC report.

A second analysis found that the mRNA vaccines are holding up well against hospitalizations for COVID-19. The research, which was conducted across 21 U.S. hospitals, found that the Pfizer and Moderna vaccines remained between 84% and 86% effective against potential hospitalizations from March to July of this year. A third analysis, conducted in New York State, found that all three authorized vaccines remained more than 90% effective at preventing hospitalization from early May to late June.

-ABC News' Sony Salzman, Eric Strauss