National Security Council spokesman John Kirby would not discuss the Israeli strike that hit Gaza's Jabaliya refugee camp on Tuesday, but he did say broadly that the U.S. believes Israel is "trying to minimize" civilian casualties in Gaza.

"It's obvious to us that they are, that they are trying to minimize,” Kirby said.

He said that assessment is based on the "daily conversation we are having with our counterparts about their goals, the strategies, and their plans."

"We’re not going to react to every event in real time, but will certainly recognize that civilians have been hurt, civilians have been killed, to the tune of many thousands, that infrastructure has been damaged by these airstrikes," Kirby said. "We’re not accepting of any single civilian death in Gaza. They’re all tragedies. And we continue to work … with the Israelis about the need to respect human life and to try to limit civilian casualties."

Following repeated warnings from President Joe Biden and his administration for Israel to follow the "rules of war," ABC News asked Kirby if a strike like this on a refugee camp would mean they violated that, but Kirby would not speculate on the explosion, saying he had no information on what occurred.

The Israeli Defense Forces has taken responsibility for the strike at the Jabaliya refugee camp, which is one of the most densely populated areas in the Gaza Strip. The IDF said the blast killed a Hamas official and claimed the official was one of the leaders of the Oct. 7 attack on Israel.

-ABC News' Justin Ryan Gomez

At Tuesday's hearing before the Senate Committee on Appropriations, Defense Secretary Lloyd Austin was asked several times about Iran's role in Hamas' Oct. 7 ambush on Israel.

Austin said that while Iran helped enable the attack, he has not seen evidence that Tehran played a direct role.

But Austin added that Iran has "funded, resourced, enabled, trained Hamas operatives," which "means that they have a big part in this."

-ABC News' Matt Seyler

Another 66 aid trucks with food, water and medicine arrived in Gaza over the last 24 hours -- the "highest single-day delivery so far" -- and "dozens of more trucks are expected to clear today," National Security Council spokesman John Kirby said Tuesday.

But "it’s a trickle compared to what needs to get in," Kirby said, "and we’re gonna keep working that, very, very hard.”

Kirby said the U.S. is continuing to push for safe passage for civilians in Gaza and the resumption of essential services, including water and fuel.

Kirby also said President Joe Biden is set to speak with Jordan's King Abdullah II on Tuesday "to discuss further cooperation with Arab partners to address the worsening humanitarian situation."

-ABC News' Justin Ryan Gomez

A massive blast has been reported at the Jabalia refugee camp in Gaza, which is one of the most densely populated areas in the Gaza Strip.

The Hamas-run Gaza Interior Ministry claims Israeli aircraft dropped six bombs on the residential area.

The Israeli Defense Forces took responsibility for the strike, saying the blast killed a Hamas official who the IDF claimed was one of the leaders of the Oct. 7 attack on Israel.

The "elimination [of Hamas commander Ibrahim Biari] was carried out as part of a wide-scale strike on terrorists and terror infrastructure belonging to the Central Jabalia Battalion, which had taken control over civilian buildings in Gaza City," the IDF said. "The strike damaged Hamas’ command and control in the area, as well as its ability to direct military activity against IDF soldiers operating throughout the Gaza Strip."

The IDF did not acknowledge the civilian deaths and casualties but repeated the warning that residents of Gaza should move south for safety.

Secretary Blinken and Prime Minister Netanyahu met earlier this morning behind closed doors and are now meeting with the Israeli War Cabinet, according to the pool producer on the ground.

"Prime Minister Benjamin Netanyahu is now holding a private meeting with US Secretary of State Antony Blinken, at the Kirya in Tel Aviv. They will also meet with the members of the War Cabinet," the Israeli PM tweeted.