At least 50 people have been confirmed dead in Israel's strike on Rafah, with a number of victims are still under the rubble, the Gaza Health Ministry said in a statement Monday. Ambulance and civil defense crews cannot reach them the victims, the statement noted.

Since Oct. 7, 36,050 people have been killed in Gaza and 81,026 others have been injured.

"Never before in history has such a large number of mass killing tools been amassed and employed together in front of the world as is happening now in Gaza, where the population is deprived of water, food, medicine, electricity, and fuel, crushing the infrastructure, destroying all institutions, disrupting sanitation, spreading epidemics, crushing the health system, implementing the siege, closing crossings, and preventing the entry of medical supplies and delegations," the Gaza Health Ministry said.

-ABC News' Will Gretsky

An Egyptian border guard was killed in a shooting in the Rafah border area with Gaza, Egypt’s military spokesman said in a statement on Monday.

"The Egyptian armed forces, through the competent authorities, are investigating a shooting incident in the Rafah border area which led to the martyrdom of one of the security personnel on duty," the statement said.

The Israeli military had earlier reported an exchange of fire on the Egyptian border and said it was discussing the incident with Egypt.

“A few hours ago (Monday), a shooting incident occurred on the Egyptian border. The incident is under review and discussions are being held with the Egyptians,” the IDF said.

Initial investigations into an incident that killed an Egyptian border guard indicate the incident occurred while there was an exchange of fire between Israeli forces and "the Palestinian resistance," an Egyptian security source told Egypt’s state-affiliated Al Qahera News TV on Monday.

In October 2023, weeks after the war started, Israel said one of its military tanks mistakenly fired at an Egyptian position near the border with Gaza. Egypt said at the time that several army personnel were slightly injured.

Tensions between Egypt and Israel have escalated after Israeli forces earlier this month seized control of the Rafah border crossing, a key entry point for humanitarian aid. Egypt said it would not reopen its side of the crossing unless it is operated by Palestinians and accused Israel of preventing aid deliveries.

-ABC News' Ayat Al-Tawy

The images that have emerged after the Israeli strike on Rafah are a "testament to how Rafah has turned into hell on earth," Philippe Lazzarini, commissioner general of the United Nations Relief and Works Agency for Palestine Refugees in the Near East, said in a post on X.

"Children and women living in tented plastic makeshift shelters are among the killed. Many were injured. Others were reportedly burnt to death. The images from last night are testament to how Rafah has turned into hell on earth," Lazzarini said went on.

Some UNRWA staff are unaccounted for and it’s very hard to establish contact with UNRWA teams in Rafah, Lazzarini said, adding that the UNRWA is doing its best to bring aid to people in need in Gaza.

"UNRWA is doing everything possible not to interrupt the delivery of humanitarian assistance. But with every day passing, providing assistance & protection becomes nearly impossible," he said.

-ABC News' Ellie Kaufman

The "devastating images" coming out of Rafah are "heartbreaking," a White House National Security Council spokesperson said in a statement Monday, adding that even though Israel "has a right to go after" Hamas, the country also has to protect civilians.

"Israel has a right to go after Hamas, and we understand this strike killed two senior Hamas terrorists who are responsible for attacks against Israeli civilians," the spokesperson said. "But as we’ve been clear, Israel must take every precaution possible to protect civilians."

The spokesperson also said that the U.S. is engaging with the Israeli authorities to figure out "what happened" in addition to the IDF investigation.

-ABC News' Michelle Stoddart