Israel-Gaza updates: 22, including 18 children, reported dead in Rafah strikes

The IDF says it struck military targets of terrorist organizations in Gaza.

Israel launched a retaliatory strike against Iran early Friday morning local time, a senior U.S. official told ABC News.

The strike followed Iran's attack on Saturday, when Tehran sent a volley of more than 300 drones and missiles toward targets in Israel, according to Israeli military officials. All but a few were intercepted by Israel and its allies, including the United States, officials said.

Iran's weekend attack came more than six months after Hamas terrorists invaded Israel on Oct. 7, after which the Israeli military began its bombardment of Gaza.


What to know about Iran's attack on Israel

Israeli officials said the country's Iron Dome defense system endured a big test from Iran's attack on Saturday, intercepting 99% of the 300 "threats of various types" thrown at it.

Iran's Islamic Revolutionary Guard Corps, according to Israel Defense Forces spokesperson Daniel Hagari, launched 170 unmanned aerial vehicles (UAVs), more than 120 ballistic missiles and more than 30 cruise missiles in the attack.

Hagari said "99% of the threats launched towards Israeli territory were intercepted -- a very significant strategic achievement."

Hagari said the attack resulted in only one known Israeli casualty, a 7-year-old girl who was severely injured when she was struck by shrapnel apparently from an intercepted missile.


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In meeting with Israelis, US officials 'expressed concerns' over Rafah

In a Thursday meeting between U.S. and Israeli officials, the two sides discussed the attack by Iran as well as the Israeli military's plans for an operation in Rafah in Gaza, according to the White House.

During the meeting, the "U.S. participants expressed concerns with various courses of action in Rafah," according to a White House readout.

"Israeli participants agreed to take these concerns into account and to have further follow up discussions between experts, overseen by the U.S.-Israel Strategic Consultative Group," and the officials agreed to meet again "soon," according to the White House.

National security adviser Jake Sullivan convened the meeting and the Israeli side was led by Minister for Strategic Affairs Ron Dermer and national security adviser Tzachi Hanegbi.


Israel makes significant process in preparations for Rafah evacuations: Source

Israel has made significant progress in preparations for the evacuation of around 1 million civilians from Rafah ahead of the Israeli military’s impending operation in the southern Gaza city, according to an Israeli source.

Preparations have been ongoing for over a month, including repairing water and sewage pipes and amassing thousands of tents, the source said.

There are around 1.5 million Palestinians estimated to be in the Khan Younis and Rafah areas in southern Gaza. It’s believed around 1 million people would evacuate north. The evacuation process, which could take weeks, would not start until after Passover.

State Department principal deputy spokesperson Vedant Patel stressed to reporters that "any kind of forced relocation or displacement of the Palestinian people within Gaza cannot and should not be part of any plan or an operation."

-ABC News’ Matt Gutman and Anne Flaherty


US, Israeli officials to hold high-level meeting on Rafah plans

U.S. and Israeli officials will hold a high-level, virtual meeting on Thursday about alternative plans for an Israeli military operation in Rafah, a White House official confirmed to ABC News.

The official said that it will be a secure video meeting that will follow up on discussions from earlier this month. National security adviser Jake Sullivan will lead the meeting for the U.S. side, the official said.

The meeting was first reported by Axios.

"The main purpose really is to talk about Rafah ... and also share our continued concerns over a major ground offensive there," White House National Security Communications Adviser John Kirby said.

-ABC News’ Michelle Stoddart


US sanctions 16 people, 2 groups after Iran attacks

The U.S. is sanctioning two groups and 16 people it says enabled Iran's drone production following Iran's attack on Israel last weekend.

"Today, in coordination with the United Kingdom and in consultation with partners and allies, we are taking swift and decisive action to respond to Iran’s unprecedented attack on Israel," Treasury Secretary Janet Yellen said. "We’re using Treasury’s economic tools to degrade and disrupt key aspects of Iran’s malign activity, including its UAV program and the revenue the regime generates to support its terrorism."

The Treasury Department said it’s sanctioning Khuzestan Steel Company, Iran's largest steel producer. The Treasury Department said Iran's metals sector generates "several billion dollars in revenue annually."

The U.S. is also targeting the Iranian carmaker Bahman Group for its role in making vehicles used by the Islamic Revolutionary Guard Corps for military operations.

The sanctions also target people who work for Iran-based drone manufacturers, including executives of the Mado Company, which the U.S. says produced drone engines used in Iran's Shahed UAVs. The U.S. also sanctioned members of the IRGC who it says help supply proxy groups, like the Houthis in Yemen, with drones that have attacked U.S. service members in the Red Sea.

Yellen added that the U.S. would "continue to deploy" sanctions to counter any further action by Iran, with the goal of making it harder and more expensive for Iran to undertake destabilizing actions.

President Joe Biden said in a statement that these sanctions are "holding Iran accountable."

Biden emphasized that the sanctions are in coordination with the international community, and he said the other G7 countries are committed to increasing "economic pressure" on Iran alongside the U.S.

Biden said he has instructed his team to continue to impose sanctions that will degrade Iran's military capabilities.

Biden also reiterated his ironclad support for Israel, and issued a warning to Iran and those who "enable" Iran's attacks.

"We are committed to the security of our personnel and partners in the region," Biden said. "And we will not hesitate to take all necessary action to hold you accountable."

-ABC News’ Michelle Stoddart and Justin Gomez


Biden calls for cease-fire 'now' to get aid into Gaza in Univision interview

President Joe Biden called for an immediate cease-fire to get food and aid into Gaza in an interview airing Tuesday night on Univision.

"So I what I'm calling for is for the Israelis to just call for a cease-fire, allow for the next six, eight weeks total access to all food and medicine going into the country," Biden said in the interview with Univision's Enrique Acevedo. "I've spoken with everyone from the Saudis to the Jordanians to the Egyptians. They're prepared to move in. They're prepared to move this food in. And I think there's no excuse to not provide for the medical and the food needs of those people. It should be done now."

Biden did not mention tying the cease-fire to a hostage deal, according to a transcript of the interview, which would be a shift for the administration. ABC News has reached out to the White House for comment.

Last week, officials pushed back on suggestions that they were separating calls for a cease-fire from hostage negotiations in their readout of Biden's call with Israeli Prime Minister Benjamin Netanyahu.

"Our conviction remains that we need to see an immediate cease-fire to enable the release of hostages but also to enable a dramatic surge in humanitarian assistance, as well as obviously better protecting civilians," Secretary of State Antony Blinken said on April 4.

In the Univision interview, Biden also called Netanyahu's approach in Gaza "a mistake" when asked if he believed the prime minister was "more concerned about his political survival than he is in the national interest of his people" as calls for Netanyahu's resignation have increased following the strike that killed seven World Central Kitchen workers.

"Well, I will tell you, I think what he's doing is a mistake. I don't agree with his approach. I think it's outrageous that those four, three vehicles were hit by drones and taken out on a highway where it wasn't like it was along the shore, it wasn't like there was a convoy moving there, etc.," Biden said in the interview.

The hour-long interview, which is airing at 10 p.m. ET, was taped a day before Biden's call with Netanyahu on April 4.

-ABC News' Molly Nagle