Israel-Gaza updates: 22, including 18 children, reported dead in Rafah strikes
The IDF says it struck military targets of terrorist organizations in Gaza.
Israel launched a retaliatory strike against Iran early Friday morning local time, a senior U.S. official told ABC News.
The strike followed Iran's attack on Saturday, when Tehran sent a volley of more than 300 drones and missiles toward targets in Israel, according to Israeli military officials. All but a few were intercepted by Israel and its allies, including the United States, officials said.
Iran's weekend attack came more than six months after Hamas terrorists invaded Israel on Oct. 7, after which the Israeli military began its bombardment of Gaza.
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What to know about Iran's attack on Israel
Israeli officials said the country's Iron Dome defense system endured a big test from Iran's attack on Saturday, intercepting 99% of the 300 "threats of various types" thrown at it.
Iran's Islamic Revolutionary Guard Corps, according to Israel Defense Forces spokesperson Daniel Hagari, launched 170 unmanned aerial vehicles (UAVs), more than 120 ballistic missiles and more than 30 cruise missiles in the attack.
Hagari said "99% of the threats launched towards Israeli territory were intercepted -- a very significant strategic achievement."
Hagari said the attack resulted in only one known Israeli casualty, a 7-year-old girl who was severely injured when she was struck by shrapnel apparently from an intercepted missile.
Iran's Islamic Revolutionary Guard Corps says extensive missiles, drones launched
Iran's Islamic Revolutionary Guard Corps announced that it has launched extensive missile and drone operations against targets in Israel, according to Tasnim, the Iranian news-agency affiliated with the branch of Iran's armed forces.
An Israeli source also confirmed to ABC News that Iran fired cruise missiles from Iraq as well.
In a post on X, the Iranian Foreign Minister said "necessary warning has been given to America."
What US officials expect in the coming hours
The U.S. will try to help Israel intercept everything possible -- not just those that pass over U.S. ships -- despite Iran informing the U.S. that they should stay out of it, a senior U.S. official confirmed to ABC News.
In the coming hours the U.S. expects missile launches from Iran and southern Lebanon -- and maybe even the Houthis -- as well as drones, which take longer to reach target. The Iranians are trying to overwhelm the Israeli air defenses with drones and missiles coming in at different altitudes, speeds and directions -- but hitting targets at the same time, according to the official.
While the U.S. expects that most of these will be intercepted -- upwards of 85% -- the fear is that if any Israeli lives are lost, the Israeli response will be much bigger.
The target is believed to be three military bases, especially one where F-35s are kept. While these bases are relatively remote, there are towns nearby and these Iranian weapons are not completely accurate.
The U.S. has no doubt Israel will respond whether lives are lost or not. And that Iran itself will be targeted.
-ABC News' Martha Raddatz
Wide concern in the White House that Iran's retaliatory attack will cause widespread war
Sources at the White House say there’s deep concern that an Iranian retaliatory strike against Israel -- and the possible Israeli response -- will widen this war.
President Joe Biden cut his weekend vacation short to consult with his national security team in preparation for this. They’ve been on high alert and knew this attack was imminent.
U.S. officials the military is prepared to provide assistance to defend Israel against attacks if needed.
The U.S. is already moving military assets to the region to deter Iran and help protect U.S. forces. Officials say they have been urging Iran against further escalation or attacks on U.S. forces. They’ve been stressing that the U.S. was not involved in the Damascus, Syria, strike earlier this month.
-ABC News' Selina Wang
Iran's leader confirms attack on Israel, says 'evil regime will be punished'
Iran's leader has confirmed that a retaliatory attack on Israel has begun.
"The evil regime will be punished", Iran's Supreme Leader Ayatollah Ali Khamenei said in a statement on X.
Iranian state TV also confirmed the attack in a banner.
"The extensive drone operation of the Islamic Revolutionary Guard Corps against targets in the occupied territories has started a few minutes ago," the banner said.
Biden calls for cease-fire 'now' to get aid into Gaza in Univision interview
President Joe Biden called for an immediate cease-fire to get food and aid into Gaza in an interview airing Tuesday night on Univision.
"So I what I'm calling for is for the Israelis to just call for a cease-fire, allow for the next six, eight weeks total access to all food and medicine going into the country," Biden said in the interview with Univision's Enrique Acevedo. "I've spoken with everyone from the Saudis to the Jordanians to the Egyptians. They're prepared to move in. They're prepared to move this food in. And I think there's no excuse to not provide for the medical and the food needs of those people. It should be done now."
Biden did not mention tying the cease-fire to a hostage deal, according to a transcript of the interview, which would be a shift for the administration. ABC News has reached out to the White House for comment.
Last week, officials pushed back on suggestions that they were separating calls for a cease-fire from hostage negotiations in their readout of Biden's call with Israeli Prime Minister Benjamin Netanyahu.
"Our conviction remains that we need to see an immediate cease-fire to enable the release of hostages but also to enable a dramatic surge in humanitarian assistance, as well as obviously better protecting civilians," Secretary of State Antony Blinken said on April 4.
In the Univision interview, Biden also called Netanyahu's approach in Gaza "a mistake" when asked if he believed the prime minister was "more concerned about his political survival than he is in the national interest of his people" as calls for Netanyahu's resignation have increased following the strike that killed seven World Central Kitchen workers.
"Well, I will tell you, I think what he's doing is a mistake. I don't agree with his approach. I think it's outrageous that those four, three vehicles were hit by drones and taken out on a highway where it wasn't like it was along the shore, it wasn't like there was a convoy moving there, etc.," Biden said in the interview.
The hour-long interview, which is airing at 10 p.m. ET, was taped a day before Biden's call with Netanyahu on April 4.
-ABC News' Molly Nagle