Secretary of State Antony Blinken condemned Iran's attack on Israel, saying the U.S. doesn't seek escalation but will support Israel's right to defend itself and will protect U.S. personnel in the Middle East.

"The United States condemns Iran's attack on Israel in the strongest terms," Blinken said in a statement.

He added that he'll be "consulting with allies and partners in the region and around the world in the hours and days ahead."

-ABC News' Shannon K. Crawford

Two U.S. officials confirmed that U.S. forces shot down about 70 Iranian drones headed towards Israel.

One official added that one of the U.S. Navy destroyers in the eastern Mediterranean was also able to bring down an undetermined number of Iranian ballistic missiles.

One of the officials said the destroyer shot down three Iranian ballistic missiles.

-ABC News’ Luis Martinez

The Israel Defense Forces Aerial Defense Array successfully intercepted the majority of Iran's surface-to-surface missile launches using the "Arrow" Aerial Defense System, together with Israel's strategic allies, before the launches crossed into Israeli territory.

A small number of hits were identified, including at an IDF base in southern Israel, where minor damage was caused to infrastructure.

Over the past few hours, many dozens of hostile aircraft, as well as dozens of cruise missiles, from Iran were identified approaching Israeli territory and intercepted. Dozens of IAF fighter jets are currently operating to intercept all aerial threats approaching Israeli territory.

According to a situation analysis by IDF’s Home Front Command, the residents of the following towns: Northern Golan, Nevatim, Dimona, Eilat-City, Be'er Sheva and Arad no longer need to stay near a protected space.

The IDF said it is deployed on all fronts, prepared, and continuing to defend Israeli territory.

-ABC News' Will Gretsky

The U.S. helped "Israel take down nearly all of the incoming drones and missiles," President Joe Biden said in a statement late Saturday evening.

The president also detailed his call with Israeli Prime Minister Benjamin Netanyahu following the attacks, where Biden said he reaffirmed America's "ironclad commitment to the security of Israel." He also said that his team would stay in "close touch" with Israel's leaders.

Biden said his team will engage with the G7 leaders on Sunday to coordinate a "united diplomatic response to Iran’s brazen attack."

He noted that though American forces were not impacted, forces will continue to monitor and "will not hesitate to take all necessary action to protect our people."
-ABC News' Michelle Stoddart

Israeli military officials on Sunday said the Iranian attack had been "thwarted" by Israel and its allies, but warned that the threat of further strikes continued.

Most of the more than 300 drones, missiles and other threats Iran launched were intercepted by Israeli and allied defenses before entering Israel, the Israel Defense Forces said.

"99% of the threats launched towards Israeli territory were intercepted -- a very significant strategic achievement," IDF spokesperson Daniel Hagari said.

The military defense was coordinated with a group of international allies, including the United States, United Kingdom and France, Hagari said.

"This partnership has always been robust, but last night it was exceptionally evident," he said.

The attack included at least 170 uncrewed drones, none of which made it into Israeli territory, he said.

About 25 of the 30 cruise missiles launched were intercepted by Israeli fighter jets before entering Israel, Hagari said.

And more than 120 ballistic missiles were launched, with "only a few" striking targets within Israel, he said. Those that made it through struck Nevatim Air Force Base, causing "minor damage to infrastructure," he said. The base remained open, he added.

"However, it is important to say -- the event is not over," Hagari said. "We remain prepared and ready for further developments and threats."

-ABC News' Edward Szekeres and Kevin Shalvey