Israel-Gaza updates: 22, including 18 children, reported dead in Rafah strikes
The IDF says it struck military targets of terrorist organizations in Gaza.
Israel launched a retaliatory strike against Iran early Friday morning local time, a senior U.S. official told ABC News.
The strike followed Iran's attack on Saturday, when Tehran sent a volley of more than 300 drones and missiles toward targets in Israel, according to Israeli military officials. All but a few were intercepted by Israel and its allies, including the United States, officials said.
Iran's weekend attack came more than six months after Hamas terrorists invaded Israel on Oct. 7, after which the Israeli military began its bombardment of Gaza.
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What to know about Iran's attack on Israel
Israeli officials said the country's Iron Dome defense system endured a big test from Iran's attack on Saturday, intercepting 99% of the 300 "threats of various types" thrown at it.
Iran's Islamic Revolutionary Guard Corps, according to Israel Defense Forces spokesperson Daniel Hagari, launched 170 unmanned aerial vehicles (UAVs), more than 120 ballistic missiles and more than 30 cruise missiles in the attack.
Hagari said "99% of the threats launched towards Israeli territory were intercepted -- a very significant strategic achievement."
Hagari said the attack resulted in only one known Israeli casualty, a 7-year-old girl who was severely injured when she was struck by shrapnel apparently from an intercepted missile.
US warns of policy changes if Israel doesn't take action to better protect civilians
President Joe Biden spoke Thursday with Israeli Prime Minister Benjamin Netanyahu, their first conversation since seven aid workers from World Central Kitchen were killed in Israeli airstrikes in Gaza.
Biden had strongly condemned the incident, which Israel's said was unintentional, saying he was "outraged."
Biden further expressed to Netanyahu that the strikes on the food relief workers and the overall humanitarian crisis in Gaza are "unacceptable," according to a White House readout of the call.
For the first time, the White House hinted the president may consider a change in U.S. policy with respect to Gaza if Israel doesn't take action to better protect civilians and aid workers.
"He made clear the need for Israel to announce and implement a series of specific, concrete, and measurable steps to address civilian harm, humanitarian suffering, and the safety of aid workers," the readout read. "He made clear that U.S. policy with respect to Gaza will be determined by our assessment of Israel’s immediate action on these steps."
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-ABC News' Molly Nagle and Alexandra Hutzler
Iran says issue 'closed' after retaliatory strike on Israel
The Iranian envoy to the United Nations said Sunday that "the issue can be considered closed," referencing Iran's attack on Israel.
The envoy also warned the U.S. to "stay away" from the escalating conflict between the two countries.
"If the Israeli regime makes another mistake, the response of the Islamic Republic of Iran will be considerably more severe," the envoy said, referring to Israel's strike earlier this month on Iran's Consulate in Damascus, Syria, that killed a top Iranian military leader. "This is a conflict between Iran and the rogue regime of Israel, and America should stay away from it."
Iran's state news agency IRNA also reported Sunday that the Islamic Revolutionary Guard Corps (IRGC) issued a stern warning to the U.S. "against supporting and participating in any action that harms Iranian interests. In its statement, the IRGC threatened "a reciprocal and proportional response to American and Israeli threats originating from any country."
The Iranian foreign minister posted on his X account: "Exercising the right of legitimate defense shows Iran's responsible approach to regional and international peace and security. At this point, the Islamic Republic of Iran has no intention of continuing defensive operations, but if necessary, it will not hesitate to protect its legitimate interests against any new aggression."
-ABC News' Somayeh Malekian and Dana Savir