Israel-Gaza updates: 22, including 18 children, reported dead in Rafah strikes
The IDF says it struck military targets of terrorist organizations in Gaza.
Israel launched a retaliatory strike against Iran early Friday morning local time, a senior U.S. official told ABC News.
The strike followed Iran's attack on Saturday, when Tehran sent a volley of more than 300 drones and missiles toward targets in Israel, according to Israeli military officials. All but a few were intercepted by Israel and its allies, including the United States, officials said.
Iran's weekend attack came more than six months after Hamas terrorists invaded Israel on Oct. 7, after which the Israeli military began its bombardment of Gaza.
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What to know about Iran's attack on Israel
Israeli officials said the country's Iron Dome defense system endured a big test from Iran's attack on Saturday, intercepting 99% of the 300 "threats of various types" thrown at it.
Iran's Islamic Revolutionary Guard Corps, according to Israel Defense Forces spokesperson Daniel Hagari, launched 170 unmanned aerial vehicles (UAVs), more than 120 ballistic missiles and more than 30 cruise missiles in the attack.
Hagari said "99% of the threats launched towards Israeli territory were intercepted -- a very significant strategic achievement."
Hagari said the attack resulted in only one known Israeli casualty, a 7-year-old girl who was severely injured when she was struck by shrapnel apparently from an intercepted missile.
Iran will respond in 'seconds' if Israel strikes back: Iranian official
If Israel strikes back, the response speed from Iran "will be less than a few seconds," said Ali Bagheri Kani, the deputy foreign minister of Iran for political affairs.
Iran did not give US heads up on Israel attack: Pentagon
Maj. Gen. Pat Ryder, the Pentagon press secretary, said Monday that Iran did not give the U.S. an advanced notice of its attack on Israel.
"I think what you're asking was did Iran give us a heads up? No, they did not," Ryder said, without indicating whether the U.S. learned of Iran's plans through allies.
Ryder said U.S. forces in the Middle East intercepted dozens of missiles and unmanned aerial vehicles when Iran and its proxies launched attacks in retaliation for Israel's strike earlier this month on the Iranian Consulate in Damascus, Syria, that killed an Iranian military leader.
Ryder repeated assessments that 99% of incoming Iranian fire was intercepted by Israel and its partners, but he wouldn't confirm reports that half of the launches failed to get off the ground.
Secretary of Defense Lloyd Austin, Ryder said, has spoken with Israeli Defense Minister Yoav Gallant three times since the attack.
"During their most recent call yesterday, the two leaders reviewed the successful combined operation by the United States, Israel and their partners to defend Israel from these unprecedented attacks by Iran and its proxies and emphasize that while the United States does not seek escalation, we will continue to take all necessary action to defend Israel and U.S. personnel," Ryder said.
Asked whether the response to Iran's attack depleted the air defense resources of Israel and its partners, Ryder declined to answer.
"As we demonstrated this weekend, we have the capability and the capacity to defend Israel and to defend our forces in the region," he said.
-ABC News' Chris Boccia and Matt Seyler
Iranian attack 'will be met with a response': Israeli military chief
As Israel's Chief of the General Staff Herzi Halevi met with troops at the Nevatim Airbase, where Iranian missiles struck over the weekend, he said Israel is weighing possible response actions.
"As we look forward, we weigh our steps, and this launch of so many missiles, cruise missiles, UAVs to the territory of the State of Israel will be met with a response," Halevi said.
-ABC News’ Jordana Miller
US to Israel: If you strike back at Iran, you'll do it alone
As Israel on Monday weighed its response to Iran’s weekend attack, the U.S. is privately telling officials there: If Israel strikes back militarily, it will do so alone.
It's an unusual message for a close ally that's spent decades receiving more U.S. military aid than any other country in the world and whose relationship with America is often described as "ironclad."
But after months of Israel acting on its own in Gaza -- and facing tough criticism from the U.S. and other allies that its military operations have gone too far – the Biden administration made clear the U.S. wouldn't participate in offensive military operations against Iran, fearing a broader war in the Middle East.
"We believe Israel has freedom of action to protect itself and defend itself," a senior administration official told reporters shortly after Iran's attack ended. "That's a long-standing policy, and that remains."
When asked by a reporter if the U.S. would help Israel counter with offensive military operations, the official said no.
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-ABC News’ Anne Flaherty
Israel says Iran fired dozens of drones
Iran has launched dozens of drones toward Israel, but it could take hours for them to reach, according to Israel Defense Forces spokesperson Daniel Hagari.
Israel is closing down its airspace after midnight local time and Israel's defense systems are deployed, according to Prime Minister Benjamin Netanyahu.
"We are prepared for any scenario, both in defense and attack," Netanyahu said in a video statement.
"The IDF is on high alert and is constantly monitoring the operational situation. The IDF Aerial Defense Array is on high alert, along with IAF fighter jets and Israeli Navy vessels that are on a defense mission in Israeli airspace. The IDF is monitoring all targets," the IDF said in a statement.
"We ask the public to adhere to and follow the instructions of the Home Front Command and the official IDF announcements regarding the matter," the statement added.