Israel-Gaza updates: 22, including 18 children, reported dead in Rafah strikes
The IDF says it struck military targets of terrorist organizations in Gaza.
Israel launched a retaliatory strike against Iran early Friday morning local time, a senior U.S. official told ABC News.
The strike followed Iran's attack on Saturday, when Tehran sent a volley of more than 300 drones and missiles toward targets in Israel, according to Israeli military officials. All but a few were intercepted by Israel and its allies, including the United States, officials said.
Iran's weekend attack came more than six months after Hamas terrorists invaded Israel on Oct. 7, after which the Israeli military began its bombardment of Gaza.
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What to know about Iran's attack on Israel
Israeli officials said the country's Iron Dome defense system endured a big test from Iran's attack on Saturday, intercepting 99% of the 300 "threats of various types" thrown at it.
Iran's Islamic Revolutionary Guard Corps, according to Israel Defense Forces spokesperson Daniel Hagari, launched 170 unmanned aerial vehicles (UAVs), more than 120 ballistic missiles and more than 30 cruise missiles in the attack.
Hagari said "99% of the threats launched towards Israeli territory were intercepted -- a very significant strategic achievement."
Hagari said the attack resulted in only one known Israeli casualty, a 7-year-old girl who was severely injured when she was struck by shrapnel apparently from an intercepted missile.
Yellen to Iran: US 'will not hesitate' to issue new sanctions
Treasury Secretary Janet Yellen is warning Iran that the U.S. "will not hesitate" to impose new sanctions in response to Iran's "unprecedented attack" on Israel.
"Treasury will not hesitate to work with our allies to use our sanctions authority to continue disrupting the Iranian regime’s malign and destabilizing activity," Yellen is expected to say at a Tuesday press conference. "The attack by Iran and its proxies underscores the importance of Treasury's work to use our economic tools to counter Iran's malign activity."
Yellen's message follows President Joe Biden's Sunday meeting with the G7 nations, during which the leaders discussed a coordinated effort on sanction measures.
-ABC News’ Justin Ryan Gomez
Israeli war cabinet to consider response again Tuesday
Prime Minister Benjamin Netanyahu's war cabinet is expected to meet again on Tuesday to consider an Israeli response to Iran's weekend attack.
"We are closely assessing the situation. We remain at our highest level of readiness," Herzi Halevi, chief of staff of the Israel Defense Forces, said on Monday. "Iran will face the consequences for its actions."
Halevi added Israel would "choose our response accordingly."
-ABC News' Morgan Winsor and Somayeh Malekian
UN watchdog calls for de-escalation in Israel-Iran conflict
United Nations officials called on Tuesday for Israel and Iran to de-escalate their conflict, saying the retaliatory military attacks “violate the right to life and must cease immediately.”
“All countries are prohibited from arbitrarily depriving individuals of their right to life in military operations abroad, including when countering terrorism,” the U.N.’s Office of the High Commissioner for Human Rights said in a press release, quoting U.N. officials described as "experts."
The retaliatory strikes by both countries may constitute the “international crime of aggression by civilian and military leaders responsible,” those officials said, according to the statement.
-ABC News' Kevin Shalvey
Iran will respond in 'seconds' if Israel strikes back: Iranian official
If Israel strikes back, the response speed from Iran "will be less than a few seconds," said Ali Bagheri Kani, the deputy foreign minister of Iran for political affairs.
'Majority' of intel came from coalition partners ahead of attack: Israeli Air Force official
A senior Israeli Air Force official said that the normalization of relations with Middle Eastern countries "served us during this crucial time" this weekend.
"It has to be clear that real assets" provided Israel with "information" and an "early warning," and the "majority" of that intelligence came from the coalition, the senior Israeli Air Force official said at a Monday briefing.
In terms of the types of drones and missiles used by Iran in the Saturday night attack, the official said Israel did not face any types of missiles that it had not shot down during attacks in recent months by Iranian proxies.
The official confirmed that only "a handful" of ballistic missiles fired by Iran were not intercepted.
"Five, more or less, managed to penetrate," the official said.
He said Israel's "strategic investment" in air defense capabilities, made years ago, had paid off, and called Israel shooting down nearly all missiles a "historic success."
The official was asked if Israel would be able to withstand a similar level of attack from Iran, without the support of allies such as the U.S.
"It would be more challenging,” the official conceded, but added that Israel has capabilities "to face this kind of challenge."
-ABC News’ Tom Soufi Burridge