Israel-Gaza updates: 22, including 18 children, reported dead in Rafah strikes
The IDF says it struck military targets of terrorist organizations in Gaza.
Israel launched a retaliatory strike against Iran early Friday morning local time, a senior U.S. official told ABC News.
The strike followed Iran's attack on Saturday, when Tehran sent a volley of more than 300 drones and missiles toward targets in Israel, according to Israeli military officials. All but a few were intercepted by Israel and its allies, including the United States, officials said.
Iran's weekend attack came more than six months after Hamas terrorists invaded Israel on Oct. 7, after which the Israeli military began its bombardment of Gaza.
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What to know about Iran's attack on Israel
Israeli officials said the country's Iron Dome defense system endured a big test from Iran's attack on Saturday, intercepting 99% of the 300 "threats of various types" thrown at it.
Iran's Islamic Revolutionary Guard Corps, according to Israel Defense Forces spokesperson Daniel Hagari, launched 170 unmanned aerial vehicles (UAVs), more than 120 ballistic missiles and more than 30 cruise missiles in the attack.
Hagari said "99% of the threats launched towards Israeli territory were intercepted -- a very significant strategic achievement."
Hagari said the attack resulted in only one known Israeli casualty, a 7-year-old girl who was severely injured when she was struck by shrapnel apparently from an intercepted missile.
US warns of policy changes if Israel doesn't take action to better protect civilians
President Joe Biden spoke Thursday with Israeli Prime Minister Benjamin Netanyahu, their first conversation since seven aid workers from World Central Kitchen were killed in Israeli airstrikes in Gaza.
Biden had strongly condemned the incident, which Israel's said was unintentional, saying he was "outraged."
Biden further expressed to Netanyahu that the strikes on the food relief workers and the overall humanitarian crisis in Gaza are "unacceptable," according to a White House readout of the call.
For the first time, the White House hinted the president may consider a change in U.S. policy with respect to Gaza if Israel doesn't take action to better protect civilians and aid workers.
"He made clear the need for Israel to announce and implement a series of specific, concrete, and measurable steps to address civilian harm, humanitarian suffering, and the safety of aid workers," the readout read. "He made clear that U.S. policy with respect to Gaza will be determined by our assessment of Israel’s immediate action on these steps."
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-ABC News' Molly Nagle and Alexandra Hutzler
'No higher priority': Harris meets with American hostages' families
During a meeting at the White House on Tuesday with the families of Americans being held hostage by Hamas, Vice President Kamala Harris said there is "no higher priority than reuniting the hostages with their loved ones," according to a White House readout.
Harris also reaffirmed the United States' commitment to bringing home the remains of those hostages who have been confirmed dead, according to the readout.
Rachel Goldberg-Polin, whose 23-year-old son Hersh is being held hostage by Hamas, described the meeting with Harris as "very productive."
“There is a possibility of holding two truths,” Goldberg-Polin told reporters outside the White House. “You can believe, as we do, that it is horrible that innocent civilians in Gaza are suffering, and at the same time you can also know that it is horrible and against international law for hostages to be held against their will."
Goldberg-Polin said her son got his arm blown off during Hamas' attack at the Nova Music festival on Oct. 7. Her husband, Jonathan Polin, said that they "have no choice but to stay hopeful."
Jonathan Dekel-Chen, the father of American hostage Sagui Dekel-Chen, called on Hamas to reach a deal to release the hostages.
"We are waiting now and the world waits for Hamas to get to yes," Dekel-Chen told reporters. "It is in their court."
-ABC News' Juhi Doshi