Israel-Gaza updates: 22, including 18 children, reported dead in Rafah strikes
The IDF says it struck military targets of terrorist organizations in Gaza.
Israel launched a retaliatory strike against Iran early Friday morning local time, a senior U.S. official told ABC News.
The strike followed Iran's attack on Saturday, when Tehran sent a volley of more than 300 drones and missiles toward targets in Israel, according to Israeli military officials. All but a few were intercepted by Israel and its allies, including the United States, officials said.
Iran's weekend attack came more than six months after Hamas terrorists invaded Israel on Oct. 7, after which the Israeli military began its bombardment of Gaza.
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What to know about Iran's attack on Israel
Israeli officials said the country's Iron Dome defense system endured a big test from Iran's attack on Saturday, intercepting 99% of the 300 "threats of various types" thrown at it.
Iran's Islamic Revolutionary Guard Corps, according to Israel Defense Forces spokesperson Daniel Hagari, launched 170 unmanned aerial vehicles (UAVs), more than 120 ballistic missiles and more than 30 cruise missiles in the attack.
Hagari said "99% of the threats launched towards Israeli territory were intercepted -- a very significant strategic achievement."
Hagari said the attack resulted in only one known Israeli casualty, a 7-year-old girl who was severely injured when she was struck by shrapnel apparently from an intercepted missile.
Israel says Iran only targeted military sites
An Israeli military source told ABC News that Iran has targeted military sites only -- civilian sites were not targeted.
The Israel Defense Forces also moved up its arrival estimate: The first drones will close in on Israel an hour earlier than expected, at 1 a.m. local time, 6 p.m. ET.
US officials think there will be 400 to 500 drones, missiles launched
A senior U.S. official told ABC News they now think there will be anywhere from 400 to 500 drones and missiles launched at Israel from Iraq, Syria, southern Lebanon and the Houthis, but that the bulk will be launched from Iran.
The drones are the same kind used in Ukraine.
Israeli airspace to close at 12:30 a.m. local time
Israeli aviation authorities say they are closing the country's airspace to all flights at 12:30 a.m. local time, 5:30 p.m. ET.
Flights would be affected and advised travelers to check with their airlines for changes.
Iranian state television also announced that Tehran had launched an attack toward Israel. Iraq's state news agency quoted Transportation Minister Raqqa Saadawi as saying the country's airspace was closed.
Before the attack was announced, a FlyDubai flight from Dubai in the United Arab Emirates to Tel Aviv, Israel, turned around as it was over Saudi Arabia, flight-tracking data showed. United Airlines also canceled a Saturday flight from Newark to Tel Aviv and the return flight.
Iran's Islamic Revolutionary Guard Corps says extensive missiles, drones launched
Iran's Islamic Revolutionary Guard Corps announced that it has launched extensive missile and drone operations against targets in Israel, according to Tasnim, the Iranian news-agency affiliated with the branch of Iran's armed forces.
An Israeli source also confirmed to ABC News that Iran fired cruise missiles from Iraq as well.
In a post on X, the Iranian Foreign Minister said "necessary warning has been given to America."
Troop withdrawal was to prepare for missions, including in Rafah, Israeli defense minister says
The withdrawal Sunday of Israeli troops from Khan Younis in the southern Gaza Strip was done to prepare forces for future missions, including in Rafah, according to Israeli Defense Minister Yoav Gallant.
“The withdrawal of troops from Khan Younis was carried out once Hamas ceased to exist as a military framework in the city," Gallant said Sunday. "Our forces left the area in order to prepare for their future missions, including their mission in Rafah.”
Speaking to reporters during a visit to the Israel Defense Forces' southern command, Gallant said, "We saw examples of such missions in Shifaa, and [will see] such missions in the Rafah area. We will reach a point when Hamas no longer controls the Gaza Strip and does not function as a military framework that poses a threat to the citizens of the State of Israel."
IDF Chief of Staff Herzi Halevi also confirmed Sunday that "the war in Gaza continues" and Israel is "far from stopping."
Senior Hamas officials are still hiding in the southern Gaza Strip area, Halevi said in a statement.
"We will get to them sooner or later," Halevi said, adding that the IDF "will know how to return to fighting in the event of a truce as part of a hostage deal and that returning the hostages is a more urgent matter than other goals."
Halevi also said Israel is preparing to defend itself from a possible strike from Iran, which has vowed to retaliate against an airstrike allegedly carried out by Israel in Syria last week that killed a top Iranian commander.
Halevi said the IDF is fully prepared to deal with Tehran "in attack and defense."
-ABC News' Jordana Miller