Israel-Gaza updates: 22, including 18 children, reported dead in Rafah strikes
The IDF says it struck military targets of terrorist organizations in Gaza.
Israel launched a retaliatory strike against Iran early Friday morning local time, a senior U.S. official told ABC News.
The strike followed Iran's attack on Saturday, when Tehran sent a volley of more than 300 drones and missiles toward targets in Israel, according to Israeli military officials. All but a few were intercepted by Israel and its allies, including the United States, officials said.
Iran's weekend attack came more than six months after Hamas terrorists invaded Israel on Oct. 7, after which the Israeli military began its bombardment of Gaza.
Latest headlines:
What to know about Iran's attack on Israel
Israeli officials said the country's Iron Dome defense system endured a big test from Iran's attack on Saturday, intercepting 99% of the 300 "threats of various types" thrown at it.
Iran's Islamic Revolutionary Guard Corps, according to Israel Defense Forces spokesperson Daniel Hagari, launched 170 unmanned aerial vehicles (UAVs), more than 120 ballistic missiles and more than 30 cruise missiles in the attack.
Hagari said "99% of the threats launched towards Israeli territory were intercepted -- a very significant strategic achievement."
Hagari said the attack resulted in only one known Israeli casualty, a 7-year-old girl who was severely injured when she was struck by shrapnel apparently from an intercepted missile.
Israel says Iran only targeted military sites
An Israeli military source told ABC News that Iran has targeted military sites only -- civilian sites were not targeted.
The Israel Defense Forces also moved up its arrival estimate: The first drones will close in on Israel an hour earlier than expected, at 1 a.m. local time, 6 p.m. ET.
US officials think there will be 400 to 500 drones, missiles launched
A senior U.S. official told ABC News they now think there will be anywhere from 400 to 500 drones and missiles launched at Israel from Iraq, Syria, southern Lebanon and the Houthis, but that the bulk will be launched from Iran.
The drones are the same kind used in Ukraine.
Israeli airspace to close at 12:30 a.m. local time
Israeli aviation authorities say they are closing the country's airspace to all flights at 12:30 a.m. local time, 5:30 p.m. ET.
Flights would be affected and advised travelers to check with their airlines for changes.
Iranian state television also announced that Tehran had launched an attack toward Israel. Iraq's state news agency quoted Transportation Minister Raqqa Saadawi as saying the country's airspace was closed.
Before the attack was announced, a FlyDubai flight from Dubai in the United Arab Emirates to Tel Aviv, Israel, turned around as it was over Saudi Arabia, flight-tracking data showed. United Airlines also canceled a Saturday flight from Newark to Tel Aviv and the return flight.
Iran's Islamic Revolutionary Guard Corps says extensive missiles, drones launched
Iran's Islamic Revolutionary Guard Corps announced that it has launched extensive missile and drone operations against targets in Israel, according to Tasnim, the Iranian news-agency affiliated with the branch of Iran's armed forces.
An Israeli source also confirmed to ABC News that Iran fired cruise missiles from Iraq as well.
In a post on X, the Iranian Foreign Minister said "necessary warning has been given to America."
US 'carefully' reviewing Israel's report on WCK attack, Blinken says
U.S. officials are reviewing Israel's report on the Israel military’s attack on World Central Kitchen aid workers "very carefully" and "will be discussing its conclusions with Israeli officials and with humanitarian organizations in the days to come," Secretary of State Antony Blinken told reporters.
The Israel Defense Forces said its airstrike in Gaza that killed seven WCK aid workers on Monday came after Israeli forces misidentified a WCK worker in the convoy as a Hamas gunman.
Blinken said Israeli Prime Minister Benjamin Netanyahu "indicated" to President Joe Biden in their Thursday call "that Israel would be making further changes to its procedures to make sure that those who are providing assistance to people who so desperately need it in Gaza are protected."
"It's very important that Israel is taking full responsibility for this incident. It's also important that it appears to be taking steps to hold those responsible accountable," Blinken said. "Even more important is making sure that steps are taken going forward to ensure that something like this can never happen again."
Blinken said the U.S. would be "looking to see not just what steps are being taken, but the results that follow" from potential changes to Israeli military operations.
-ABC News’ Chris Boccia