Israel-Gaza updates: 22, including 18 children, reported dead in Rafah strikes

The IDF says it struck military targets of terrorist organizations in Gaza.

Israel launched a retaliatory strike against Iran early Friday morning local time, a senior U.S. official told ABC News.

The strike followed Iran's attack on Saturday, when Tehran sent a volley of more than 300 drones and missiles toward targets in Israel, according to Israeli military officials. All but a few were intercepted by Israel and its allies, including the United States, officials said.

Iran's weekend attack came more than six months after Hamas terrorists invaded Israel on Oct. 7, after which the Israeli military began its bombardment of Gaza.


What to know about Iran's attack on Israel

Israeli officials said the country's Iron Dome defense system endured a big test from Iran's attack on Saturday, intercepting 99% of the 300 "threats of various types" thrown at it.

Iran's Islamic Revolutionary Guard Corps, according to Israel Defense Forces spokesperson Daniel Hagari, launched 170 unmanned aerial vehicles (UAVs), more than 120 ballistic missiles and more than 30 cruise missiles in the attack.

Hagari said "99% of the threats launched towards Israeli territory were intercepted -- a very significant strategic achievement."

Hagari said the attack resulted in only one known Israeli casualty, a 7-year-old girl who was severely injured when she was struck by shrapnel apparently from an intercepted missile.


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Israeli war cabinet meeting ends again with no final decision on response: Source

Prime Minister Benjamin Netanyahu's war cabinet met for the third day in a row on Tuesday to consider an Israeli response to Iran's weekend attack.

But Tuesday’s meeting ended with no final decision made about an Israeli response, according to an Israeli source with knowledge of the meeting. A variety of options are still being considered, the source said.


Iran foreign minister says 'no intention of further escalating the situation'

Iranian Foreign Minister Hossein Amir-Abdollahian told Chinese Foreign Minister Wang Yi on a call that "Iran is willing to exercise restraint and has no intention of further escalating the situation," according to the Chinese foreign ministry’s readout of the conversation.


More than 19,000 children orphaned in Gaza

Over 10,000 women have been killed in Gaza during the war, according to a report from UN Women, the United Nations’ entity for gender equality and women's empowerment.

Out of those 10,000 women, 6,000 were mothers, who have left behind 19,000 orphaned children, according to the report.

-ABC News’ Kori Skillman


Israel focused too intensely on Iran's nuclear threat at expense of ballistic threat: IDF

Israel Defense Forces spokesman Rear Adm. Daniel Hagari said Israel focused too intensely on the Iranian nuclear threat at the expense of its ballistic threat.

A senior U.S. official told ABC News the U.S. also relied too heavily on the misguided conception that Iran's Supreme Leader Ayatollah Ali Khamenei was cautious and would never order a direct attack on Israel, and that this weekend’s attack and the general U.S. assessment of Iran now requires study and reassessment.

Sima Shine, a former head of the Iran desk at Israeli espionage agency Mossad, also said Israel’s assessment was wrong, and said "the rules of the game" have changed. A huge barrage of missiles was considered possible, but highly unlikely, Shine said.

Shine said any Israeli response under the new conception requires the assumption that Iran will follow up with its threat of another salvo of missiles. That said, Shine believes that Iran and the supreme leader do not want a full-scale war because it would be unpopular in Iran and the U.S. could get involved.

-ABC News’ Matt Gutman


US sanctions 16 people, 2 groups after Iran attacks

The U.S. is sanctioning two groups and 16 people it says enabled Iran's drone production following Iran's attack on Israel last weekend.

"Today, in coordination with the United Kingdom and in consultation with partners and allies, we are taking swift and decisive action to respond to Iran’s unprecedented attack on Israel," Treasury Secretary Janet Yellen said. "We’re using Treasury’s economic tools to degrade and disrupt key aspects of Iran’s malign activity, including its UAV program and the revenue the regime generates to support its terrorism."

The Treasury Department said it’s sanctioning Khuzestan Steel Company, Iran's largest steel producer. The Treasury Department said Iran's metals sector generates "several billion dollars in revenue annually."

The U.S. is also targeting the Iranian carmaker Bahman Group for its role in making vehicles used by the Islamic Revolutionary Guard Corps for military operations.

The sanctions also target people who work for Iran-based drone manufacturers, including executives of the Mado Company, which the U.S. says produced drone engines used in Iran's Shahed UAVs. The U.S. also sanctioned members of the IRGC who it says help supply proxy groups, like the Houthis in Yemen, with drones that have attacked U.S. service members in the Red Sea.

Yellen added that the U.S. would "continue to deploy" sanctions to counter any further action by Iran, with the goal of making it harder and more expensive for Iran to undertake destabilizing actions.

President Joe Biden said in a statement that these sanctions are "holding Iran accountable."

Biden emphasized that the sanctions are in coordination with the international community, and he said the other G7 countries are committed to increasing "economic pressure" on Iran alongside the U.S.

Biden said he has instructed his team to continue to impose sanctions that will degrade Iran's military capabilities.

Biden also reiterated his ironclad support for Israel, and issued a warning to Iran and those who "enable" Iran's attacks.

"We are committed to the security of our personnel and partners in the region," Biden said. "And we will not hesitate to take all necessary action to hold you accountable."

-ABC News’ Michelle Stoddart and Justin Gomez