Israel-Gaza updates: 22, including 18 children, reported dead in Rafah strikes
The IDF says it struck military targets of terrorist organizations in Gaza.
Israel launched a retaliatory strike against Iran early Friday morning local time, a senior U.S. official told ABC News.
The strike followed Iran's attack on Saturday, when Tehran sent a volley of more than 300 drones and missiles toward targets in Israel, according to Israeli military officials. All but a few were intercepted by Israel and its allies, including the United States, officials said.
Iran's weekend attack came more than six months after Hamas terrorists invaded Israel on Oct. 7, after which the Israeli military began its bombardment of Gaza.
Latest headlines:
What to know about Iran's attack on Israel
Israeli officials said the country's Iron Dome defense system endured a big test from Iran's attack on Saturday, intercepting 99% of the 300 "threats of various types" thrown at it.
Iran's Islamic Revolutionary Guard Corps, according to Israel Defense Forces spokesperson Daniel Hagari, launched 170 unmanned aerial vehicles (UAVs), more than 120 ballistic missiles and more than 30 cruise missiles in the attack.
Hagari said "99% of the threats launched towards Israeli territory were intercepted -- a very significant strategic achievement."
Hagari said the attack resulted in only one known Israeli casualty, a 7-year-old girl who was severely injured when she was struck by shrapnel apparently from an intercepted missile.
Israel says Iran only targeted military sites
An Israeli military source told ABC News that Iran has targeted military sites only -- civilian sites were not targeted.
The Israel Defense Forces also moved up its arrival estimate: The first drones will close in on Israel an hour earlier than expected, at 1 a.m. local time, 6 p.m. ET.
US officials think there will be 400 to 500 drones, missiles launched
A senior U.S. official told ABC News they now think there will be anywhere from 400 to 500 drones and missiles launched at Israel from Iraq, Syria, southern Lebanon and the Houthis, but that the bulk will be launched from Iran.
The drones are the same kind used in Ukraine.
Israeli airspace to close at 12:30 a.m. local time
Israeli aviation authorities say they are closing the country's airspace to all flights at 12:30 a.m. local time, 5:30 p.m. ET.
Flights would be affected and advised travelers to check with their airlines for changes.
Iranian state television also announced that Tehran had launched an attack toward Israel. Iraq's state news agency quoted Transportation Minister Raqqa Saadawi as saying the country's airspace was closed.
Before the attack was announced, a FlyDubai flight from Dubai in the United Arab Emirates to Tel Aviv, Israel, turned around as it was over Saudi Arabia, flight-tracking data showed. United Airlines also canceled a Saturday flight from Newark to Tel Aviv and the return flight.
Iran's Islamic Revolutionary Guard Corps says extensive missiles, drones launched
Iran's Islamic Revolutionary Guard Corps announced that it has launched extensive missile and drone operations against targets in Israel, according to Tasnim, the Iranian news-agency affiliated with the branch of Iran's armed forces.
An Israeli source also confirmed to ABC News that Iran fired cruise missiles from Iraq as well.
In a post on X, the Iranian Foreign Minister said "necessary warning has been given to America."
US sanctions 16 people, 2 groups after Iran attacks
The U.S. is sanctioning two groups and 16 people it says enabled Iran's drone production following Iran's attack on Israel last weekend.
"Today, in coordination with the United Kingdom and in consultation with partners and allies, we are taking swift and decisive action to respond to Iran’s unprecedented attack on Israel," Treasury Secretary Janet Yellen said. "We’re using Treasury’s economic tools to degrade and disrupt key aspects of Iran’s malign activity, including its UAV program and the revenue the regime generates to support its terrorism."
The Treasury Department said it’s sanctioning Khuzestan Steel Company, Iran's largest steel producer. The Treasury Department said Iran's metals sector generates "several billion dollars in revenue annually."
The U.S. is also targeting the Iranian carmaker Bahman Group for its role in making vehicles used by the Islamic Revolutionary Guard Corps for military operations.
The sanctions also target people who work for Iran-based drone manufacturers, including executives of the Mado Company, which the U.S. says produced drone engines used in Iran's Shahed UAVs. The U.S. also sanctioned members of the IRGC who it says help supply proxy groups, like the Houthis in Yemen, with drones that have attacked U.S. service members in the Red Sea.
Yellen added that the U.S. would "continue to deploy" sanctions to counter any further action by Iran, with the goal of making it harder and more expensive for Iran to undertake destabilizing actions.
President Joe Biden said in a statement that these sanctions are "holding Iran accountable."
Biden emphasized that the sanctions are in coordination with the international community, and he said the other G7 countries are committed to increasing "economic pressure" on Iran alongside the U.S.
Biden said he has instructed his team to continue to impose sanctions that will degrade Iran's military capabilities.
Biden also reiterated his ironclad support for Israel, and issued a warning to Iran and those who "enable" Iran's attacks.
"We are committed to the security of our personnel and partners in the region," Biden said. "And we will not hesitate to take all necessary action to hold you accountable."
-ABC News’ Michelle Stoddart and Justin Gomez